低钾性周期性麻痹84例临床研究.doc

低钾性周期性麻痹84例临床研究[摘要] 目的：总结低钾性周期性麻痹（hypoKPP）的临床表现和疗效，探讨其发病机制及预防措施。方法：回顾分析84例确诊的低钾性周期性麻痹患者的临床资料。结果：84例患者中，原发性60例，其中有家族史者5例，散发54例；继发性24例，其中继发于甲亢者19例。有心电图资料者62例，其中，正常10例，有典型低血钾改变者52例。伴有四肢麻木者6例，肌肉酸痛者5例。经过口服和静脉注射钾后，全部病例均获得痊愈。结论：血清钾及心电图的检查有利于早期诊断及治疗。继发性者要加强原发病治疗，避免各种诱因是防止复发的关键。 [关键词] 低钾性麻痹；离子通道；骨骼肌瘫痪 [中图分类号] R591 [文献标识码]A [文章编号]1673-7210（2007）12（b）-029-02 The clinical analysis of 84 patients with hypokalemic periodic paralysis SU Ya-bi (Mining Industry Hospital of Yuxi,Yuxi 653100,China) [Abstract] Objective:To explore the pathogenesy and the precaution of the hypokalemic periodic paralysis by summarizing the clinical situation and therapeutic effect. Methods:The clinical data of 84 patients with hypokalemic periodic paralysis were retrospectively analyzed.Results:There were 60 primarily patients,5 of them had family history,54 of them were diverging.There were 24 patients sequented by other diseases.19 patients were followed by the hyperthyreosis.62 patients had ECG data,10 of them were nomal and 52 of them were typical hypokalemic.6 patients combined limbs anesthesia, 5 patients combined muscle acid. All patients were cured by taking potassium orally and intravenous injection.Conclusion:The primarily hypoKPP is a autosomal dominant inheritanced ion channel disease. Thyrotoxic Periodic Paralys is most common within the sequented hypoKPP.The test of serum potassium and the ECG are benefit to the early diagnosis and therapy of hypoKPP.The sequented patients should cure the primary diease,It?s a key to prevent recrudescent to avoid all kinds of motivation. [Key words] Hypokalemic periodic paralysis ; Ion channel; Muscle paralysis 低钾性周期性麻痹(hypoKPP)是一种与离子通道异常有关的常染色体显性遗传疾病，临床上以周期性发作的骨骼肌弛缓性瘫痪伴发作时血钾降低为特点[1]。我们收集本院1997~2007年间病史资料完整的急诊及住院患者共84例，分析其临床特征与辅助检查结果，探讨其发病机制及预防措施。 1 资料与方法 1.1一般资料 84例患者中，男65例，女19例。年龄18~67岁，平均35岁，其中40岁以下64例(76.1%)。首次发作30例，反复2次以上发作45例。起病至就诊时间为2 h~3 d，平均12 h。发作持续时间2 h~3 d，80例患者在1 d内完全恢复。原发性60例， 其中阳性家族史5例。继发性中甲亢19例，诱因依次包括：剧烈运动或劳累