关于胃泌素及T淋巴细胞在不同程度老年慢性萎缩性胃窦炎中表达探究.doc

关于胃泌素及T淋巴细胞在不同程度老年慢性萎缩性胃窦炎中表达探究[摘要] 目的 探讨不同程度老年慢性萎缩性胃窦炎中胃泌素、T淋巴细胞的表达情况。方法 共有研究对象52例，均为胃镜及病理检查确诊为慢性萎缩性胃窦炎患者，根据患者的病情程度分为轻度、中度和重度组；并以患者是否伴有不典型增生及肠化分组;比较各组患者的胃泌素及T淋巴细胞水平。结果 与轻度组比较，重度组的胃泌素及CD4水平差异有统计学意义（P＜0.05）；与伴有不典型增生及肠化组比较，不伴有组的胃泌素、CD4、CD8、CD4/CD8无显著性差异（P＞0.05）。结论 在老年慢性萎缩性胃窦炎患者中检测其胃泌素及T淋巴细胞的水平能够对其疾病的诊断起到一定的辅助作用。 [关键词]老年慢性萎缩性胃窦炎；胃泌素；T淋巴细胞 [中图分类号] R573.3+2 [文献标识码] B [文章编号] 1673-9701（2011）32-44-02 Expression of Gastrin and T Lymphocytes in Varying Degrees of Chronic Atrophic Antral Gastritis HE Junhui1 ZOU Xiuling2 LI Zhongchu1 LU Zhongkui3 1. Department 3 of Internal Medicine, Guangdong Province Foshan City Shunde District Longjiang Hospital, Foshan 528318, China; 2.Department of Tumor, Guangdong Province Foshan City Shunde District Longjiang Hospital, Foshan 528318, China；3. Department of Laboratory, Guangdong Province Foshan City Shunde District Longjiang Hospital, Foshan 528318, China [Abstract] Objective To investigate the expression of gastrin and T lymphocytes in varying degrees of chronic atrophic antral gastritis. Methods Fifty-two cases were diagnosed with endoscopy and pathology, they were divided into mild, moderate and severe group according to the patient’s severity; and divided into two groups according to associate with dysplasia and intestinal metaplasia or not; Compared the gastrin and T lymphocytes. Results Compared mild group,the difference in gastrin and CD4 levels of severe group were significantly （P＜0.05）; Compared associated dysplasia and intestinal metaplasia group, gastrin, CD4, CD8, CD4/CD8 of not associated group were no significant difference（P＞0.05）. Conclusion It is play a supporting role in diagnosis of disease that elderly patients with chronic atrophic antral gastritis detect gastrin and T lymphocytes. [Key words] Chronic atrophic antral gastritis; Gastrin; T Lymphocytes 萎缩性胃窦炎的确诊多是采用胃镜及病理组织检查[1]。由于有一部分老年萎缩性胃窦炎患者不适合胃镜检查，使疾病不能及时地得到诊断及采取相应的治疗措施。寻找一种新的诊断方法对于疾病的诊断具有非常重要的作用。近几年临床上胃窦炎及胃癌的筛查中越来越重视血清学检查。笔者将对近年来我院就诊的老年萎缩性