玉竹林-252中子近距离放射治疗.pdf.docVIP

一项回顾性研究对锎-252中子近距离放射治疗相结合EBRT与食管鳞状细胞癌的治疗疗效  Background Worldwide, an estimated 482,000 new esophageal cancer cases were diagnosed and approximately 407,000 deaths occurred in 2008 [1]. The management of localized esophageal cancers has shifted from surgery or radiation single modality approaches to the trimodality. The current trimodality approach combining chemotherapy, radiation therapy, and surgery, has shown improved survival rates * Correspondence: chris.wang@ 3Medical Physics Program, School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332-0745, USA Full list of author information is available at the end of the article  [2]. However, there are patients that either cannot tolerate or decide not to undergo surgery. For these individuals, concurrent chemoradiotherapy (CCRT) is the standard approach. In recent years, two radiotherapy modalities have become widely used in China to treat esophageal cancers: the neutron brachytherapy in combination with conventional external beam radiotherapy (NBT + EBRT) and the 3-dimensional conformal radiotherapy (3D-CRT). Currently there are no prospective, randomized trials comparing the efficacy of the two modalities for the treatment of esopha-geal cancer. The choice between the two modalities is not  ? 2015 Wang et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Wang et al. Radiation Oncology (2015) 10:212 Page 2 of 8  trivial, and their characteristics can have bearing on both disease control and adverse effe