卡维地洛联合参松养心胶囊对高血压伴阵发性房颤患者P波离散度影响.doc

卡维地洛联合参松养心胶囊对高血压伴阵发性房颤患者P波离散度影响【摘要】目的：探讨卡维地洛联合参松养心胶囊对高血压伴阵发性心房颤动（PAF）P波离散度（Pd）的影响。方法：83例PAF患者，随机分成4组：卡维地洛实验组21例；参松养心胶囊实验组20例；联合用药组21例；对照组21例。实验组给予药物干预，观察药物对Pd及PAF发生率的影响。结果：实验组3个月后PAF的发生率、Pd较对照组明显降低， 但是卡维地洛实验组，参松养心胶囊实验组和联合用药组间的Pd无显著差异。结论：单用卡维地洛或参松养心胶囊可以通过降低Pd来减少高血压患者PAF的发作。但是联用这两种药物却不能取得更好的效果。 【关键词】心房纤颤；卡维地洛；参松养心胶囊；心电图；P波离散度 文章编号：1009-5519（2008）01-0024-03 中图分类号：R25 文献标识码：A Therapeutic effect ofcarvedilol combined with shensongyangxin capsule on P wave dispersion in hypertensive patients with paroxymal atrial fibrillation QUAN Tie，FAN Liang-jun，LU Qing-shan，et al. (The People’s Hospital of Shimen，Hunan 415300，China) 【Abstract】Objective：To investigate the therapeutic effect ofcarvedilol combined with shensongyangxin capsule on P wave dispersion(Pd) in hypertensive patients with paroxymal atrial fibrillation(PAF).Methods：83 hypertensive patients with PAF were divided into 4 groups,control group，carvedilol treatment group， shensongyangxin capsule treatment group and both drug treatment group randomly. Pd was measured based on the electrocardiogram at the beginning and the third month after taking medicine.Results：There was no significant difference in Pd among 4 groups(P0.05).Pd was decreased after 3 months of treatment compared with that before treatment (P0.05). Conclusion：Carvedilol or shensongyangxin capsule is helpful to prevent the recurrence of PAF， while carvedilol combined with shensongyangxin capsule can not get a better therapeutic effect. 【Key words】Atrial fibrillation；Carvedilol；Shensongyangxin capsule；Electrocardiogram；P wave dispersion 阵发性心房颤动（PAF）是一种常见的心律失常，易引起严重的心脑血管病且容易复发，而P波离散度（Pd）可作为预测PAF的体表心电图指标[1]。本研究旨在通过研究卡维地洛与参松养心胶囊对Pd的影响，而对其控制高血压伴PAF复发的作用进行比较。 1 对象与方法 1.1 研究对象：选择2002年5月~2007年5月我院门诊和住院高血压伴AF患者83例，男45例，女38例，年龄40~88岁（平均年龄63.54±10.70岁），均经常规心电图或动态心电图证实，平均每月均有1次以上的PAF发作，实验前两周内未应用?茁受体阻滞剂、钙通道阻滞剂、血管紧张素转化酶抑制剂和各类抗心率失常药物。随机分为4组：卡维地洛实验组21例，除给予利尿剂外加卡维地洛治疗，初始剂量10 mg，日1次，2日后增至10 mg，日2次；参松养心胶囊实验组20例除给予利尿剂治疗外，加参松养心胶囊4粒，日3次；联合用药组21例