小儿咳嗽变异性哮喘及支原体感染关系探究.doc

小儿咳嗽变异性哮喘及支原体感染关系探究[摘要] 目的：探讨小儿咳嗽变异性哮喘（CVA）与支原体感染关系。方法：通过选取本院2006年1月~2010年1月儿科门诊咳嗽变异性哮喘患儿108例为观察组，同期就诊、年龄相仿的上呼吸道感染的患儿100为对照组，使用间接血球凝集法测定方法对两组患儿的MP-IgM进行测定，观察组的MP-IgM（+）患儿使用大环内酯类进行治疗。结果：观察组108例患儿中MP-IgM（+）患儿46例，占42.59%，对照组MP-IgM（+）患儿11例，占11%。46例CVA合并MP-IgM（+）患儿在常规治疗基础上加用大环内酯类，总有效率为95%。对46例患儿进行为期7~24个月的随访，仅有2例患儿咳嗽轻度发作。结论：小儿咳嗽变异性哮喘与肺炎支原体感染有密切的关系，大环内酯类对此类患儿疗效显著。 [关键词] 小儿咳嗽变异性哮喘； 肺炎支原体；阿奇霉素；大环内酯类药物 [中图分类号] R720.5 [文献标识码]A[文章编号]1674-4721（2011）07（c）-063-02 The relation of pediatric cough variant asthma and mycoplasma infection LI Weiguang,LING Zhengtao, LI Hongmei Pediatrics Department of Pingyuan Country People’s Hospital inMeizhou City, Guangdong Province, Pingyuan 514600, China [Abstract] Objective: To investigate the relation of pediatric cough variant asthma and mycoplasma infection. Methods: Selected 108 children with pediatric cough variant asthma from January 2006 to January 2010 as treatment group, choose the similar age andsame period of the upper respiratory tract infection of children of the 100 as control group, detected the MP-IgM by using indirect hemagglutination blood determination method in two groups of children. Results: 46 cases(42.59%) in treatment group were MP-IgM(+),11 cases(11%) in control group were MP-IgM(+). 46 cases CVA with MP IgM (+) in treatment group with conventional treatment combined with macrolides, the total effective rate was 95%. In 46 cases for a 7-24 months of follow-up, only 2 cases cough mild attacked. Conclusion: There is a close relation in pediatric cough variant asthma and mycoplasma pneumoniae infection, Macrolides,curative effect is distinct. [Key words] Pediatric; Cough variant asthma; Mycoplasma infection; Macrolides 咳嗽变异性哮喘（CVA）又叫做咳嗽型哮喘，是以慢性咳嗽为主要或唯一临床表现的一种特殊类型哮喘。根据临床研究发现，CVA在发病早期时大约有5%~6%患者是以持续性咳嗽为主要症状[1]，大多数发生在夜间或凌晨，常为刺激性咳嗽，常常被误诊为支气管炎。CVA的GINA中明确规定咳嗽变异性哮喘是哮喘的一个类型，其病理生理和哮喘相同，和气道高反应性有关。近年来，临床研究发现小儿咳嗽变异性哮喘与支原体感染有关，为了探讨这种关系，笔者通过对本院2006年1月~2010年1月儿科门诊患儿进行对比观察，具体报道如下： 1 资料与方法 1.1一般资料 选取本院2006