急性缺血性脑血管病患者代谢综合征及颈动脉粥样硬化相关性研究.doc

急性缺血性脑血管病患者代谢综合征及颈动脉粥样硬化相关性研究[摘要] 目的 分析急性缺血性脑血管病（AICD）患者代谢综合征（MS）对颈动脉粥样硬化（CA）的影响。方法 对124例观察组AICD患者及100例对照组健康人群行彩色多普勒超声仪检查颈动脉，比较两组CA与MS的发生率及颈动脉内中膜厚度、斑块指数。将观察组分成有CA的A组及无CA的B组，分析两组MS的患病率以及MS和其单一组分危险因素与CA的相关性。结果 观察组MS与CA发生率、IMT、斑块指数均明显高于对照组，差异具有统计学意义（P＜0.05）；A组年龄与MS、高血压、糖尿病、三酰甘油增高、低密度脂蛋白胆固醇增高及总胆同醇增高的发生率均高于B组，差异具有统计学意义（P＜0.05）；与CA相关的危险因素依次为MS、高血压、糖尿病、年龄、LDL-C增高、TG增高、TC增高、吸烟（P＜0.05）。结论 AICD患者MS及CA发生率高，MS是CA的独立危险因素，其各单一组分危险因素均增加CA的发生。 [关键词]急性脑缺血；代谢综合征；颈动脉粥样硬化 [中图分类号] R743.3 [文献标识码] B [文章编号] 1673-9701（2011）24-60-02 Analysis of Metabolic Syndrome and Carotid Atherosclerosis in Patients with Acute Ischemic Cerebrovascular Diseases ZHOU Lin Neurology Department，Zhoushan Hospital in Zhejiang Province，Zhoushan 316000，China [Abstract] Objective To analysis the relation between metabolic syndrome（MS） of cerebrovascular diseases（AICD） and carotid atherosclerosis（CA）. Methods Color Dopple ultrasound was used to examine the carotid artery of 124 patients with AICD and 100 healthy subjects as control group．The IMT，the occurrence rate of CA and MS were compared between two groups．Patients with AICD were divided into A group and B group according to the occurrerlce situation of CA；the prevalence of MS and the correlation between MS and single risk factor were analyzed．Results The prevalence of MS，IMT，carotid plaque index and the occurrence rate of CA in the AICD group were all significantly higher than those in the control group（P＜0.05）．The prevalence of MS，and the incidence of hypertension and high levels of TG，LDL-C and TC in the A group were significantly increased than those in the B group（P＜0.05）．The prevalence of MS and the incidence of hypertension and high levels of TG，LDL-C and TC，smoke were relevant to CA（P＜0.05）. Conclusion The prevalence of MS and CA in patients with AICD is high．The MS is positively associated with the risk of CA and its component risk factors to further impact CA． [Key words] Cerebral ischemia；Metabolic syndrome；Carotid atherosclerosis