氟比洛芬酯对鼻内镜术术后镇痛效果临床观察.doc

氟比洛芬酯对鼻内镜术术后镇痛效果临床观察[摘要] 目的：观察氟比洛芬酯注射液对鼻内镜术术后的镇痛效果及超前镇痛作用。方法：选择择期行鼻内镜术患者60例，采用随机方法分为术前给药组（A组）、术后给药组（B组）及对照组（C组），每组各20名。A组于术前15 min缓慢静脉注射氟比洛芬酯50 mg，B组于术毕缓慢静脉注射氟比洛芬酯50 mg，C组不给药，分别观察术后6 h和12 h的视觉模拟量表(VAS)评分。结果：A组和B组术后6和12 h VAS评分均显著低于C组。A组术后6 h VAS评分低于B组，但术后12 h无显著差异。结论：氟比洛芬酯注射液可有效缓解鼻内镜术术后疼痛，且术前给药优于术后给药。 [关键词] 氟比洛芬酯；鼻内镜术；术后镇痛；超前镇痛 [中图分类号] R765.9[文献标识码]B [文章编号]1673-7210（2008）05（a）-062-02 Postoperative analgesia effect with Flurbiprofen Axetil injection for nasal endoscopic operation HUANG Jia-ying1，FENG Yi-jin1，YU Jun-ma2 （1.Department of Otorhinolaryngology of Hefei First People’s Hospital，Hefei 230061，China；2.Department of Anesthesia of Hefei First People’s Hospital，Hefei 230061，China） [Abstract] Objective:To observe postoperative analgesia and preemptive analgesia of Flurbiprofen Axetil Injection for nasal endoscopic operation. Methods:A total of 60 patients undergoing nasal endoscopic operation were randomized into the preoperative injection group (group A)，postoperative injection group (group B) and control group (group C)，with 20 patients in each group. Patients in group A and group B were intravenously injected with flurbiprofen 50 mg preoperation and postoperation respectively，group C was not administrated. VAS scores were observed at 6 and 12 hours after operation.Results:VAS scores of group A and group B after 6 and 12 hours were significantly lower than group C. VAS scores of group A after 6 hours lower than group B，but there was no significant difference at 12 hours.Conclusion: Flurbiprofen Axetil Injection effectively relieves postoperative pain of nasal endoscopic operation， and preoperative treatment is better than postoperative treatment. [Key words]Flurbiprofen Axetil Injection；Nasal endoscopic operation；Postoperative analgesia；Preemptive analgesia 氟比洛芬酯是以脂微球为药物载体的非甾体类抗炎药物（NSAIDs），它具有靶向镇痛作用，且作用持久。有研究显示它在骨科、普外科、妇科术后有良好的镇痛作用。鼻内镜术由于创伤小、视野清晰、疗效好而现在被广泛用于治疗慢性鼻窦炎、鼻息肉、鼻腔良性肿瘤等鼻部疾病，但术后病人常出现不同程度的疼痛。本文研究观察了该药在鼻内镜术术后的镇痛效果。 1资料与方法 1.1临床资