疏血通盐酸丁咯地尔治疗椎-基底动脉缺血性眩晕临床探究.doc

疏血通盐酸丁咯地尔治疗椎-基底动脉缺血性眩晕临床探究【摘要】目的：观察疏血通联合盐酸丁咯地尔治疗椎-基底动脉缺血性眩晕的疗效。方法：椎-基底动脉缺血性眩晕患者160例随机分为治疗组80例及对照组80例；治疗组予盐酸丁咯地尔150 mg加入0.9%生理盐水250 ml中联合疏血通8 mg加入0.9%生理盐水250 ml中静脉滴注，每天1次，治疗10天。对照组予丹参30 ml加入0.9%生理盐水250 ml中联合脉络宁30 ml加入0.9%生理盐水250 ml中静脉滴注，每天1次，治疗10天。全部病例治疗前后均做经颅多普勒（TCD）检查。结果：治疗后两组患者症状均有改善，但治疗组疗效明显优于对照组，治疗组VA、BA血流速度较对照组明显增快(P0.01)。结论：疏血通联合盐酸丁咯地尔是治疗椎基底动脉供血不足的有效药物。 【关键词】眩晕；椎-基底动脉供血不足；疏血通；盐酸丁咯地尔 文章编号：1009-5519（2007）24-3653-02 中图分类号：R5 文献标识码：A Clinical study on the treatment of vertebro-basilar ischemia by combined injection of buflomedil hydrochloride and shuxuetong ZHU Ying-chun，CHEN Xu-cai，WANG Shun-cai，et al. （The People’s Hospital ofJurong，Jiangsu 212400，China） 【Abstract】Objective：To observe the clinical effect of buflomedil hydrochloride combined with shuxuetong in treating vertigo caused by vertebro-basilar ischemia.Methods：160 patients with vertigo caused by vertebro-basilar ischemia were randomly divided into the treatment group（treated by combined injection of buflomedil hydrochloride and shuxuetong）and the control group（treated by combined injection of dansheng and mailuoning）.All patients received the examination of TCD.Results：The difference between the two groups was significant（P0.01）.Conclusion：The clinical effect of buflomedil hydrochloride combined with shuxuetong is better than that of dansheng combined with mailuoning in treating vertigo caused by vertebro-basilar ischemia. 【Key words】Vertigo；Vertebro-basilar ischemia；Shuxuetong；Buflomedil hydrochloride 椎-基底动脉供血不足（VBI）治疗方法较多，疗效各异。我院应用疏血通联合盐酸丁咯地尔治疗椎-基底动脉供血不足患者80例，并与丹参联合脉络宁治疗80例患者作对照观察。现将结果报道如下。 1 资料与方法 1.1 一般资料：本组160例均系我院神经内科住院患者，所有病例均以眩晕为初始症状，主要症状符合VBI诊断标准[1]，患者治疗前后均行肝肾功能、血糖、心电图、经颅多普勒、CT或MRI检查。头颅CT或MRI检查排除脑梗死或出血，并排除心、肝、肾、内分泌及代谢性疾病。按随机原则分两组，治疗组80例，男60例，女20例，年龄55~79岁，平均65岁；对照组80例，男58例，女22例，年龄56~78岁，平均64.5岁。两组在年龄、性别、病程上均具可比性。 1.2 治疗方法：治疗组予盐酸丁咯地尔150 mg加入0.9%生理盐水250 ml中联合疏血通8 mg加入0.9%生理盐水250 ml中静脉滴注，每天1次，治疗10天。对照组予丹参30 ml加入0.9%生理盐水250 ml中，联合脉络宁30 ml加入0.9%生理盐水250 ml中静脉滴注，每天1次，治