补肾健脾养血活血法改善血管性认知障碍大鼠行为学障碍探究.docVIP

补肾健脾养血活血法改善血管性认知障碍大鼠行为学障碍探究[摘要] 目的：观察补肾健脾养血活血法对血管性认知障碍（VCI）大鼠行为学的影响。方法：造模前随机选取10只大鼠为假手术组，其余大鼠采用反复夹闭双侧颈总动脉结合腹腔注射硝普钠降低血压改良法建立VCI大鼠模型，造模成功后将其随机分为康欣胶囊复方组（复方组）、康欣胶囊简化方组（简方组）、西药对照组、模型组，每组10只。经过3周药物干预后，通过Morris水迷宫观察模型大鼠逃避潜伏期和穿越平台次数，测试其学习记忆能力。结果：与模型组比较，复方组、简方组、西药对照组逃避潜伏期明显缩短[（14.57±3.99）、（16.93±2.54）、（18.42±7.35）s]，穿越平台区域的次数明显增多[（6.90±1.86）、（7.20±1.75）、（6.10±2.46）次]，差异有统计学意义（P＜0.05）。结论：补肾健脾养血活血立法的康欣胶囊能明显改善VCI大鼠的行为学障碍。 [关键词] 血管性认知障碍；行为学障碍；康欣胶囊；Morris水迷宫 [中图分类号] R743 [文献标识码] A [文章编号] 1673-7210（2011）12（b）-024-03 Study of invigorating kidney and strengthening spleen, nourishing blood and promoting blood method in improving the behavior of rats with vascular cognitive impairment SHEN Shuanghong1, SHEN Xiaodong2, WU Tongyu1, GONG Degui3, MAO Jingjie1, DU Jian1 1.Research Institute of Traditional Chinese Medicine and Western Medicine, Fujian University of Traditional Chinese Medicine, Fujian Province, Fuzhou 350108, China; 2.Department of Traditional Chinese Medicine, the Second Hospital of Agricultural Reclamation in Heilongjiang Province, Jiamusi 150007, China; 3.Department of Rehabilitation, the Second People’s Hospital of Fujian Province, Fuzhou 350003, China [Abstract] Objective: To observe the impact of invigorating kidney and strengthening spleen, nourishing blood and promoting blood method on behavior of rats with vascular cognitive impairment (VCI). Methods: 10 rats were chosen randomly as sham operation group before operation, the left rats were caused by the reformed method of lowering blood pressure by clipping two sides of total artery in neck repeatedly combined with Sodium Nitrate of intraperitoneal injection to make vascular cognitive impairment model, which were randomly divided into four groups, namely Kangxin capsule compound group (compound group), Kangxin capsule simplified group (simplified group), western medicine control group and model group, with 10 rats in each group. After treatment for 3 weeks, the escape latency, the times of crossin