西帕依固龈液治疗糜烂型口腔扁平苔藓疗效观察.docVIP

西帕依固龈液治疗糜烂型口腔扁平苔藓疗效观察[摘要] 目的 观察西帕依固龈液治疗糜烂型口腔扁平苔藓的疗效。 方法 选择糜烂型扁平苔藓患者63例，随机分成两组。实验组34例采用西帕依固龈液含漱，对照组29例采用复方氯己定液含漱，将疗效进行对比观察。 结果 实验组糜烂面显著缩小，疼痛程度显著减轻，糜烂愈合时间明显短于对照组，实验组总有效率88.24%，对照组总有效率55.17%，两组比较差异均有统计学意义（P ＜ 0.05）。 结论 西帕依固龈液治疗糜烂型口腔扁平苔藓具有较好的短期临床效果。 [关键词] 西帕依固龈液；口腔扁平苔藓；糜烂 [中图分类号] R781.5 [文献标识码] B [文章编号] 1673-9701（2012）03-0081-02 Clinical efficacy of Xipayi mouth rinse in treatment of erosive oral lichen planus LIU Wei LI Fang JIN Lei Department of Stomatology, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, China [Abstract] Objective To evaluate the effect of Xipayi mouth rinse in the treatment of erosive oral lichen planus (OLP). Methods Sixty-three erosive OLP cases were chosen and randomly divided into two groups. The experimental group included 34 cases was treated with Xipayi mouth rinse, and the control group with 29 cases was treated with Compound Gargle Solution Chlorhexidine Giuconatie. The efficacy of the two groups were compared. Results Comparing the two groups, the erosion healing time of Xipayi mouth rinse was obviously shorter than that of the control group; The treated group showed that the pain was remarkbly relieved and the erosion areas were obviously smaller. The significant differences were found between the two groups (P ＜ 0.05). Conclusion Xipayi mouth rinse is effective in the treatment of erosive OLP. [Key words] Xipayi mouth rinse; Oral lichen planus; Erosion 糜烂型口腔扁平苔藓常发生于颊、唇、前庭沟、磨牙后区、舌腹等部位，在充血基础上发生糜烂，糜烂周围有白色花纹或丘疹，进食或说话疼痛明显，病程长达数月，严重影响患者的生存质量[1]。西帕依固龈液是根据维族药的理论选用西域中药没食子经现代科技制成的中药液，具有清毒祛火、清血止痛的功效。近年来，我科用西帕依固龈液局部含漱治疗糜烂型口腔扁平苔藓取得较好疗效，现报道如下。 1 资料与方法 1.1 一般资料 选择我院口腔科门诊2008年6月～2011年5月糜烂型口腔扁平苔藓患者63例，年龄32～65岁，平均44.9岁，其中女45例，男18例。病损部位均为双颊黏膜，病程均为半年以上。经病理确诊为糜烂型口腔扁平苔藓，所有病例经检查无全身系统性疾病。1个月内未使用抗生素，近3个月未接受免疫治疗。 1.2 治疗方法 63例患者按随机数字表法分为实验组34例和对照组29例：实验组给予西帕依固龈液（新疆奇康哈博维药有限公司，国药准字；对照组采用复方氯己定含漱液（深圳南粤药业有限公司，国药准字。含漱方法均为晨起、三餐后清洁口腔后及临睡前，每次含漱5～10 mL，时间为2～3 min，每日3～5次，治疗时间2周。全愈合者继续治疗7 d，然后评价2周疗效