三氯酚与环糊精之结合常数研究.PDF

三氯酚與環糊精之結合常數研究 薛仲娟 國立宜蘭技術學院化學工程學系副教授 摘 要 以紫外光光譜法決定5 種三氯酚(2,3,4- 、2,3,5- 、2,3,6- 、2,4,5-及2,4,6-三氯酚)之結構異構物與環糊精 形成內包錯合物之結合常數K 。三氯酚與環糊精作用除了依三氯酚的形狀大小與環糊精孔洞適合性 f 及疏水性作用力外，二者之間尚有氫鍵作用力，是以此五種三氯酚與環糊精有不同程度的結合力。當- 環糊精濃度增加時，其中2,3,5-及2,4,6-三氯酚與環糊精形成內包錯合物之λ 為紅位移(red shift) ，其 max 餘三種三氯酚(2,3,4- 、2,3,6-及2,4,5-)呈藍位移(blue shift) ，且此五種三氯酚之內包錯合物在λ 吸收度皆 max 呈hyperchromic 。三氯酚為有機酸，在高pH 時會解離成多氯酚陰離子，所以不同pH 時，三氯酚若為中 性分子時與環糊精之K ，比為陰離子時大。若三氯酚上之羥基若被氯阻擋者，其K 較小如2,3,6-及 f f 2,4,6-三氯酚者，三氯酚之K 最大為2,4,5-三氯酚者。 f 關鍵詞 ：紫外光光譜法、三氯酚、β-環糊精、結合常數 Determination of Formation Constants for - Cyclodextrin Complexes of Trichlorophenols Chung-Chuan Hsueh Associate professor, Department of Chemical Engineering, National I-lan Institute of Technology Abstract The formation constants of five trichlorophenols (2,3,4- 、2,3,5- 、2,3,6- 、2,4,5-及2,4,6-trichlorophenol) - cyclodextrin(-CD) complexes were determined by ultraviolet-visible (UV-VIS) spectroscopic method. Three chloro substituents of these trichlorophenols were different displacements on phenol, their structure would influence the interaction and the formation constants of inclusion complexes between trichlorophenols and -CD. The interactions of inclusion complexes were included hydrophobic interaction and hydrogen bonding. The