芪参健骨颗粒对激素性股骨头坏死大鼠血液流变和小鼠微循环.PDF

芪参健骨颗粒对激素性股骨头坏死大鼠血液流变和小鼠微循环的影响 章建华1 2* 2 2 2 ，尹华 ，李昌煜 ，林婷 ，王知青 (1.浙江中医药大学附属第一医院，杭州 310006 ；2.浙江中医药大学药学院，杭州 310053) 摘要：目的 考察芪参健骨颗粒对股骨头坏死模型大鼠血液流变学及小鼠微循环的影响。方法 血流变试验：SD 大鼠分 为正常组、模型组、低、中、高剂量给药组、阳性对照组，采用全自动血流变快测仪测量各组大鼠的血液流变值。微循 环实验：ICR 小鼠分为空白组，低、中、高剂量给药组，采用多普勒微循环仪考察各组小鼠微循环。结果 芪参健骨颗 粒能调节激素性股骨头坏死大鼠血流变，低、中剂量药物具有较好的调节血液流变学的作用；各剂量给药组均能促进小 鼠耳部微循环。结论 芪参健骨颗粒能明显改善激素性股骨头坏死模型的血流变和促进正常小鼠微循环，从而防治激素 性股骨头坏死。 关键词：芪参健骨颗粒；血液流变学；微循环 中图分类号：R285.5 文献标志码：A 文章编号：1007-7693(2012)12-1067-03 Effect of Qishen Jiangu Granule on the Hemorheological Characteristics and Microcirculation of SINFH 1 2* 2 2 2 ZHANG Jianhua , YIN Hua , LI Changyu , LIN Ting , WANG Zhiqing (1.Zhejiang Chinese Medical University First Affiliated Hospital, Hangzhou 310006, China; 2.College of Pharmacy, Zhejiang Chinese Medicine University, Hangzhou 310053, China) ABSTRACT: OBJECTIVE To investigate the effect of Qishen Jiangu granule on the hemorheological characteristics of the rat model with steriod-induced necrosis of femoral head(SINFH) and microcirculation of mice. METHODS Hemorheological test: SD rats were randomly divided into 6 groups: control group, model group, low-, medium-, high-dose group, and the positive control group, respectively. The hemorheological values of rats from each group were measured by automatic hemorheological rapid detector. Microcirculation experiment: ICR mice were divided into 5 groups namely control group, model group, and low-, medium-, high-dose group. Laser Doppler perfusion flowmeter was adopted to detecting the microcirculation of the mice from each group. RESULTS Qishen Jiangu granule could regulate the hemorheological change on the rats with SINFH, low- and medium-dose group indicated a better drug effect on all hemorheological indexes; and the drug promoted microcirculation