鼻咽癌患者治疗后质量调整生命年的研究.pdfVIP

盟癌症杂志2008年3月第23卷第2期 The Practical Journal of Cancer．March 2008．V0l 23．N0．2 · 153· · 临床研究 · 鼻咽癌患者治疗后质量调整生命年的研究 黎燕宁 农东晓 覃焕桦 冯启明 【摘要】 目的 计算鼻咽癌患者治疗后的质量调整生命年，探讨影响质量调整生命年的因素。方法 对复查的 304例鼻咽癌患者采用华盛顿大学生命质量量表简体中文第4版进行调查，以生命量表得分为权重，计算质量调整生命 年。运用相关分析、t检验和多元线性回归评价QALY的影响因素。结果 平均权重是0．70。偏相关分析说明随访时间 与QALY呈负相关，与生命质量无相关关系。结合QALY的单因素和多因素分析，提示：生命质量得分越高、N分期越 早，QALY越高，而年龄、是否复发、随访时间与之呈负相关。结论 QALY结合考虑生命质量和生存时间的损失对鼻咽 癌患者的影响，是综合评价患者疾病负担的有效方法。 【关键词】 质量调整生命年；鼻咽癌；多因素分析 中图分类号：R739．63 文献标识码：A 文章编号：1001—5930(2008)02-0153-03 Research of Quality—Adjusted Life Years in Nasopharyngeal Carcinoma Patients after Treatment L／Yah—ning NONG Dong—xiao，QlN Huan—hua，et a1． School of Public Health，Department of Epidemiology and Medical Stat~一 tics，Guangxi Medical University，Nanning，530021 【Abstract】 Objective To evaluate the quality—adjusted life year(QALY)and its influencing factors in nasopharyngeal carcinoma(NPC)patients after treatment、Methods 304 patients with nasopharyngeal carcinoma treated in our hospital were e— valuated using simplified Chinese edition of Washington University—QOL(uw—QOL)Version 4．QALY were calculated by using UW—QOL score as the weight、Correlation analysis，t test and multiple linear regression were used to evaluate the influencing fac— tors．Results The average weight was 0．70．Partial correlative analysis demonstrated that follow—up time was negatively correlated with QALY，but it was not correlated with WU—QOL．Univariate and multivariate analysis showed that QALY was related to the WU—QOL SCOre and N stage，whereas age，recurrence and follow—up time were negative correlated with it．Conclusion QALY could serve as an effective way to evaluate burden of disease in NPC patients by considering both the loss of QOL score and sur-