心肌缺血相关炎症因子的研究进展 - 中华老年多器官疾病杂志.doc

·综 述· 心肌缺血相关炎症因子的研究进展 汪 军1，孙莉莉2，李 斌3* （1阆中市人民医院骨科，阆中 637400；2第四军医大学附属西京医院神经内科，西安 710032；3松滋市人民医院心内科，松滋 434200） 【摘 要】炎症在冠状动脉粥样硬化引起心肌缺血的过程中起着关键作用，与缺血性心脏病的发生、发展、诊断、治疗和预后密切相关的炎症标志物有C反应蛋白、细胞因子、细胞黏附分子、趋化因子等。心肌缺血病理生理的基础是冠状动脉粥样斑块不稳定，发生破裂继之血栓形成，部分或完全堵塞病变的血管，从而导致不同程度的心肌缺血损伤，引发一系列病理症状。本文就C反应蛋白、白细胞介素、肿瘤坏死因子-α和转化生长因子-β在冠状动脉粥样硬化性心肌缺血的促发、介导以及维持等方面的研究进展和临床意义作一综述。 【关键词】冠状动脉疾病；心肌缺血；C反应蛋白质；白细胞介素；肿瘤坏死因子-α；转化生长因子-β 【中图分类号】 R542.2 【文献标识码】 A 【DOI】 ? Inflammatory markers related to myocardial ischemia WANG Jun1, SUN Li-Li2, LI Bin3* (1Department of Orthopaedics, Langzhong People’s Hospital, Langzhong 637400, China; 2Department of Neurology, Xi Jing Hospital, Fourth Military Medical University, Xi’an 710032, China; 3Department of Cardiology, Songzi People’s Hospital, Songzi 434200, China) 【Abstract】 Inflammation has been considered as a key role in the process of myocardial ischemia caused by the coronary atherosclerosis. The occurrence, development, path-physiological changes, diagnosis, treatment and prognosis of ischemic heart disease are closely related to the inflammatory markers such as C-reactive protein, cytokines, cell adhesion molecules and so on. The path-physiological basis of myocardial ischemia is due to unstable coronary atherosclerotic plaque, rupture following thrombosis and the partial or completed blockade of the vascular lesions. In varying degrees, it will cause myocardial ischemic injury and lead to a series of pathological symptoms. Four kinds of inflammatory markers like C-reactive protein (CRP), interleukins (IL), tumor necrosis factor-α (TNF-α) and transforming growth factor-β (TGF-β) will be reviewed, as well as their research progress and clinical significance on their influence of induction, mediation and protection in coronary atherosclerotic myocardial ischemia be discussed. 【Key words】 coronary artery disease; myocardial ischemia; C-reactive protein; interleukin; tumor necrosis factor-α; transforming growth factor-β Corresponding author: LI