ROCK与动脉粥样硬化.PDFVIP

· 690 · 生命的化学, 2013, 33(6): 690-694 《生命的化学》2013 年33 卷6 期 综述 ROCK 与动脉粥样硬化 孙倩倩，吉爱国* （山东大学威海国际生物技术研发中心，威海264209 ） Rho (Rho-associated, coiled-coil containing protein kinase, ROCK) ras 摘要： 相关的卷曲螺旋型蛋白激酶 是 同源家族RhoA (ras homolog family member A)下游的靶蛋白之一，主要功能是调节肌动蛋白细胞骨架 的活动，如细胞粘附、细胞运动、细胞迁移及细胞收缩。实验及临床研究表明ROCK可能与多种心血 管疾病如高血压、肺动脉高压、动脉粥样硬化以及脑血管疾病有着很大相关性。此篇综述将总结近期 对于RhoA/ROCK通路在调控血管功能中的关键作用并探讨其对于动脉粥样硬化相关疾病的潜在治疗 价值。 关键词：ROCK；RhoA；动脉粥样硬化；心血管疾病 ROCK: potential targets for the treatment of atherosclerosis diseases SUN Qianqian, JI Aiguo* (Shandong University International Biotechnology Research and Development Center at Weihai, Weihai 264209, China) Abstract: Rho-associated, coiled-coil containing protein kinase (ROCK), the downstream target proteins of RhoA (ras homolog family member A), plays the crucial function to regulate the activity of the actin cytoskeleton, e.g. cell adhesion, movement, migration and shrinkage. The recent experimental and clinical studies have shown that ROCK may have great correlation with a variety of cardiovascular diseases, e.g. hypertension, pulmonary hypertension, atherosclerosis and cerebral vascular diseases. This review will summarize the recent understanding of RhoA/ROCK pathway in the regulation of atherosclerosis- related disease. Key words: Rock; RhoA; atherosclerosis; cardiovascular disease Rho相关的卷曲螺旋型蛋白激酶(Rho-associated, 1 ROCK 结构以及相关通路 coiled-coil containing protein kinase, ROCK) ras 是 同 1.1 ROCK