超高场强磁共振下DBS电极周围组织的病理改变资料.pptx

;Why this topic;Indications of MR-DBS ;Contraindications on specification;Medtronic’s vouch;Introduction;Introduction;Introduction;First, take a look at reports on medical devices induced thermal injury during MR examination.;Cases;Cases;Will MR-DBS lead to burn? The mechanisms of the heating. How to ensure the safety of patients with DBS in face of MR? ;Contents;Introduction for MR heating of conducts;Magnetic Resonnance;MR principles;MR principles;Features of MR magnetic field ;RF heating;Heating mechanisms of conducts;Electromagnetic induction;2, Resonancecoils will receive RF power and induce alternating currents，producing much heat. ;Resonance;Case for resonance;Heating mechanisms of conducts;Antenna effect;Will MR cause TEMP rise?;Will MR cause TEMP rise?;Mechanisms of MR-DBS heating ;Mechanisms of MR-DBS heating;TEMP change of DBS lead;body：6.1(extra wire surrounding bur hole) 25.3(surrounding IPG) head：2.3;Extra wires into small loops with changing diameters on the level of bur hole. Left: open,Right: filled.1.5T, 3.0T.0-2.75 loops;1.5T: 1.8-10.3°C 3.0T: 0.8-7.3°C Small loops reduce heating of MR-DBS;Numerical model of MR-DBS heating;;M3389 heat distribution in different heat conduction rates （k=0.026, 30, 300）k(diamond)800-2000,k(d-like carbon)30-40;?T of DBS electrode in normal operation(0-1.75v) and MR-RF(1.75-5v);3T,7T MR-DBS, gel phantom, SAR 3, extra wire: loop; top, side, front. ?T: 3T7T, ?T: sidetopfront, max:8.2/7.6°Cexcept for side loop, 7T ?T 2°C, 3T ?T4.5°C6mm ?T slightly less than contacts.;Brain thermal damage;Cellular damage due to thermal injury;Thermal damage of the brain;Threshold for brain thermal damage;Confirmation of thermal damage;Pathological changes;Detection of heat injury;Molecular biology----HSP70;Cases;When sticking to MR guideline;Cases;Cases;Cases;Thank you for your attention!