西酞普兰治疗伴焦虑症状老年高血压疗效.docVIP

西酞普兰治疗伴焦虑症状老年高血压疗效[摘要] 目的 探讨抗抑郁剂西酞普兰治疗伴有焦虑症状的老年高血压患者的临床疗效。 方法 63例老年高血压患者，汉密顿焦虑量表（HAMA-14）评分≥14分，随机分为研究组（n = 32）与对照组（n = 31），研究组给予降压药物与西酞普兰治疗，对照组只给降压药物治疗。观察8周。 结果 治疗后两组患者的收缩压、舒张压、HAMA总分均下降，差异有统计学意义（P ＜ 0.05或P ＜ 0.01）。研究组治疗后的收缩压、舒张压、HAMA总分均低于对照组（P ＜ 0.05或P ＜ 0.01）。 结论 西酞普兰治疗老年高血压患者的焦虑症状疗效肯定，安全性好，适合作为老年患者的首选。 [关键词] 高血压；焦虑；西酞普兰 [中图分类号] R544.1 [文献标识码] A [文章编号] 1673-7210（2012）08（b）-0066-02 Effect of Citalopram in the treatment of senile hypertension with anxiety symptoms QIU Rongbin WEI Yuping ZHANG Haiqiu Guangxi University Hospital, Guangxi Zhuang Autonomous Region, Nanning 530004, China [Abstract] Objective To investigate the curative effect of antidepressant Citalopram in the treatment of senile hypertensive patients with anxiety symptoms. Methods 63 cases of senile hypertensive patients, with more than 14 points of the Hamilton anxiety scale (HAMA-14) scores, were randomly divided into study group (n = 32) and control group (n = 31). Citalopram and antihypertensive drugs were given to the patients in study group, and the patients in control group were given antihypertensive drug only. Observation was done for 8 weeks. Results The systolic blood pressure, diastolic blood pressure and total score of HAMA of all patients in both groups were significantly decreased after treatment (P ＜ 0.05 or P ＜ 0.01). And the systolic blood pressure, diastolic blood pressure and total score of HAMA of patients in study group were lower than that of control group (P ＜ 0.05 or P ＜ 0.01). Conclusion Citalopram is useful and safe for anxiety symptoms in senile hypertensive patients, it can be the first choice for senile patients. [Key words] Hypertension; Anxiety; Citalopram 随着生物-心理-社会医学模式的发展，心血管疾病与心理障碍的关系日益受到重视。一项涉及2 274例患者的调查发现，高血压总体焦虑发生率为38.5%[1]。心血管焦虑抑郁是高血压或血压升高形成的独立危险因素[2]，不仅影响高血压患者的降压治疗效果，也严重降低患者的生活质量。探讨抗抑郁剂西酞普兰治疗伴有焦虑症状的老年高血压的疗效，可为高血压病的综合治疗提供参考依据。现报道如下： 1 资料与方法 1.1 一般资料 选择2008年3月～2011年3月期间我院门诊就诊的原发性高血压患者。入组标准：①符合《中国高血压防治指南》（2005年修订版），收缩压（SBP）≥140 mm Hg（1 mm Hg=