3种方案治疗急性上尿路感染的成本-效果分析.pdfVIP

安 徽 医 药 Anhui Medical and Pharmaceutical Journal 2008 Feb；12(2) 。175‘ 3种方案治疗急性上尿路感染的成本一效果分析 王颖彦，胡 黎，林 华 (广东省中医院药学部临床药学室，广东广州 510120) 摘要：目的 对3种方案治疗急性上尿路感染进行经济学分析。方法 运用药物经济学成本一效果分析方法，对3种治疗方案 进行评价，A组：头孢呋辛；B组：左氧氟沙星，C组：阿莫西林／克拉维酸，3组治疗方法均是静脉滴注3 d后，改为口服10 d。结 果 3组药物均可治疗急性上尿路感染，其中头孢呋辛组治疗有效率与细菌清除率最高，左氧氟沙星组最为经济，但是耐药菌 株多见，治疗有效率与细菌清除率较低，阿莫西林／克拉维酸组价格最贵，治疗有效率与细菌清除率也较高。结论 头孢呋辛治 疗效果最佳，价格居中，是比较合适的选择，左氧氟沙星治疗最为经济，但是疗效最差，阿莫西林／克拉维酸价格最贵，疗效也较 好，如细菌对头孢呋辛耐药时，也是较好的选择。 关键词：上尿路感染；成本一效果分析法；头孢呋辛；左氧氟沙星，阿莫西林／克拉维酸 Cost．effectiveness analysis among three pr0jects on acute upper urinary tract infection WANG Ying—Yan，HU Li，LIN Hua (Guangdong Provincial Hospital of TCM，Guangzhou，510120) Abstract：Aim To compare the economical effects among three projeets on acute upper urinary tract infection，Methods According tO the principle of pharmacoeconomics，by using cost—effectiveness analysis(CEA) ，three projeet(group A：cefuroxime；group B：levofloxa— ein；group C：amoxicillin and clavulanate)were compared．The drugs were taken orally for 1 0 days after intravenous drip for 3 days．Re- suits Three drugs are effective on acute upper urinary tract infection．The highest values about effective power and clearance rate of bac— terium emerged in group A，and the lowest values emerged in group B，While the cost of group B is lowest，the cost of group C is highest， Conclusion Cefuroxime has the best curative effect and not expensive，SO cefuroxime is a better choice．Levofloxacin is the cheapest yet without good curative effect，Amoxieillin and clavulanate has better curative effect but is the most expensive，which will be a good choice if the resistance to cefuroxime emerges． Key words：upper urinary tract infection；cost—effectiveness analysis；cefuroxime；levofloxacin；amoxicillin and clavulanate 药物经济学(P