癫痫患儿丙戊酸钠血药浓度监测结果回顾分析.PDF

癫痫患儿丙戊酸钠血药浓度监测结果回顾分析 梅艳，汪洋，宋新文，彭静，周军(武汉市儿童医院，武汉 430016) 摘要：目的 探讨癫痫患儿丙戊酸钠血药浓度与临床疗效、给药剂量、药物剂型、性别、年龄和体质量的相关性。方法 回 顾性查阅我院临床药学室 337 例癫痫患儿丙戊酸钠血药浓度监测记录，将浓度值、性别、年龄等资料录入数据库，利用 SPSS 13.0 软件进行分析处理。结果 癫痫患儿丙戊酸钠血药浓度值与性别不存在明显的相关性，但与临床疗效、给药剂 量、药物剂型、年龄和体质量密切相关。结论 丙戊酸钠在患儿体内的代谢过程存在一定的个体差异性，应根据每位患 儿自身的具体情况并结合血药浓度监测结果来制订个体化给药方案。 关键词：癫痫；儿童；丙戊酸钠；治疗药物监测；相关性 中图分类号：R971.6; R969.11 文献标志码：B 文章编号：1007-7693(2011)02-0174-04 An Retrospectively Analysis on Results of Serum Sodium Valproate Concentration Monitoring on Children with Epilepsy MEI Yan, WANG Yang, SONG Xinwen, PENG Jing, ZHOU Jun(The Children’s Hospital of Wuhan, Wuhan 430016, China) ABSTRACT: OBJECTIVE To investigate the correlations of serum sodium valproate concentration in epileptic children with clinical therapeutic effect, dosage, dosage form, sex, age and body weight. METHODS Our clinical pharmacy room’s 337 cases monitoring records of serum sodium valproate concentration in children with epilepsy were researched retrospectively and data as concentrations, sex, age etc were put into data base, which were analyzed and treated by SPSS 13.0 software. RESULTS No significant correlation was noted between serum sodium valproate concentration in epileptic children and sex, however it was closely correlated with therapeutic effect, dosage, dosage form, age and body weight. CONCLUSION The individual difference in the metabolic processes of sodium valproate within individual patient was obvious, so it’s necessary to make individualized remedy according to patients’ specific condition and monitoring result. KEY WORDS: epilepsy; children; sodium valproate; therapeutic drug monitoring; correlation 丙戊酸钠(sodium valproate，VPA)通常作为癫 例。涉及的患儿均符合国际抗癫痫联盟(ILAE)最新 痫全面性发作的首选药物，也可用于部分性发作、 的癫痫发作类型及对癫痫诊断的建议[3] 。其中门诊 Lennox-Gastaut 综合征及热性惊厥等症的治疗[1] 。 258 例，住院79 例；男性219 例，女性 118 例； 因其广谱高效，无镇静作用，不影响认知功能等