BioPathways Consortium课件.pptVIP

BioPathways Consortium CB-SIG 2002 Hallmarks of Cancer Systems Biology: A New Paradigm Broad Range of Applications Platform for Systems Biology What are the Goals of the BioPathways Consortium? Goals Identify the informatics needs of Pathways analyses within a Systems Biology context What are current and future Applications Offer a forum for both academia and industry to discuss how these needs should be met Propose practical info-organizational models (formalisms) as solutions to the challenges Offer a “sandbox” for new algorithm research to which the life science community has access Publish our findings and models Challenges What do we mean by pathways? Are there different kinds? How do we represent each kind? Is one single representation useful and practical? How do we intend to apply them to life sciences? How do we incorporate our ever-changing knowledge of life sciences? How can it be applied to high-throughput analyses? Can it support hypothesis-driven research? 2002 Agenda Formalisms – Vincent Schachter,Aviv Regev Text Mining Initiative – Andrey Rhzetsky, Eric Neumann Pathway Reconstruction – Dana Pe’er Coordination with I3C – Vincent Schachter, Erich Minch Coordination with ISCB Next Meeting at ISMB 02, Edmonton, Canada 2002 Agenda Formalisms – Vincent Schachter,Aviv Regev Text Mining Initiative – Andrey Rhzetsky, Eric Neumann Pathway Reconstruction – Dana Pe’er Coordination with I3C – Vincent Schachter, Erich Minch Coordination with ISCB Next Meeting at ISMB 02, Edmonton, Canada Formalisms: Models, Ontologies, Data Interchange Formats, etc. KEGG Model metabolomics transcriptomics aMAZE Model – Wodak van Heldenintegrated metabolomics, transcriptomics proteomics The Need for Interactions Semantics Phosphorylation, allosteric binding, competitive inhibition, chaperoning, transporting, Link with GO? Types of Interactions(courtesy of K. Kohn) Functional Scales of Systems PathOS.daml ?xml version=1.0 encoding=ISO-8859-1? !DOCTYPE rdf:RDF [ !