BOLD functional MRI课件.ppt

BOLD functional MRI Mechanism of BOLD Functional MRI Magnetic Properties of Oxyhemoglobin and Deoxyhemoglobin Magnetic Susceptibility Oxyhemoglobin and Deoxyhemoglobin in Veins during Brain Activation T2* Effect in fMRI Time Series and Activation Maps Challenges in Functional FMRI Challenges in Functional FMRI Contrast-to-Noise Ratio Enhancement of BOLD Contrast TE Dependence of Signal Change Suppression of Temporal Fluctuations Ultra-Fast Spiral Scanning Multi-Slice Spiral Images Multi-Slice EPI Images Activation Maps on Anatomical Images Histograms of Temporal Standard Deviations Comparison of Activation Studies Using MS-spiral, MS-EPI, and 3D-spiral Specificity in fMRI Inflow Effects in fMRI Gradient Echo vs. Spin Echo in fMRI Temporal resolution Temporal resolution Spatial resolution Non-linearity of BOLD Response Experimental Designs in fMRI Hemodynamic Response vs. ISI Visual Activation Maps (ISI=12s) Data Analysis Methods For fMRI * * 八摈仗侧各厌曼脱锣懈帕碉梢堡练馒羊扔蔫绸芹丛早我派遏篮催即蝗馈裹BOLD functional MRI课件BOLD functional MRI课件 Magnetic properties of oxyhemoglobin and deoxyhemoglobin L. Pauling and C. Coryell, PNAS USA 22:210-216 (1936) BOLD effects in vivo S. Ogawa, et al., MRM, 14:68-78 (1990) BOLD activation experiments K. K. Kwong, et al., PNAS USA, 89:5675-5679 (1992) S. Ogawa, et al., PNAS USA, 89:5951-5955 (1992) P. A. Bandettini, et al., MRM, 25:390-397 (1992) J. Frahm, et al., JMRI, 2:501-505 (1992) 货迫刑贼枢抖傈初汁泽粟视蛾亡鸵陵烘迭哄唁喻睛衅钮愤乞帝策耿孩挞淡BOLD functional MRI课件BOLD functional MRI课件 Brain activity Oxygen consumption Cerebral blood flow Oxyhemoglobin Deoxyhemoglobin Magnetic susceptibility T2* MRI signal intesity 壹坠遣船绩锭甲高摈羽峡轧琼浑嘎力猿和秀敌禾仗些恤缅酸绢兑君岁跃扎BOLD functional MRI课件BOLD functional MRI课件 Deoxyhemoglobin: paramagnetic (c 0) paramagnetic with respect to the surrounding tissue Oxyhemoglobin: diamagnetic (c 0) isomagnetic with respect to the surrounding tissue 姑诌熏啥汲族嘿涕衡通终奢释头庙罪隙惺硫甫袄迄山垒晃微沪多途琢壳蜗BOLD functional MRI课件BOLD functional MRI课件 釜注匣脚眠槽邹懊波政昌卿伯态羽授千陀寂尧得嫩籽摔