力竭运动对大鼠大脑P2X1、P2X3、P2X5和P2X7受体表达的影响.pdfVIP

·798· 周未艾李硕 陈海涛 国家体育总局体育科学研究所(北京100061) 和P2X，的时相性变化特点。方法：健康成年雄性SD大鼠68只，分为一次力竭游泳运动组和反复力竭 游泳运动组及安静对照组。反复力竭组大鼠每日负重3％体重进行力竭游泳运动，共训练2周。运动组 达率在运动后各时点只在一定范围内波动。(2)反复力竭组运动后12dx时4种受体亚型相对表达率 均达到峰值．较其它各时间点及安静对照组、一次力竭12dx时均有显著差异(P0．01)。结论：4种受 体亚型表达率在反复力竭运动后12／b时出现峰值．提示4种P2X受体亚型参与的中枢神经活动在力 竭运动后12／1时可能达到一个活跃期。 关键词P2Xl；P2X3；P2X5；P2X7；大脑；力竭运动；大鼠 Exercise FeatureofVariationin and inRatBrainafterExhaustive P2X7 P2Xl，P2Xs，P2X5 Zhou Haitao Weiai，LiShfiX)，Chen ChinaInstitute 100061 ofsportsScience，Beijing，China uthor：ZhouWeiai，Email：zhouweiai@ciss．Clt Correjpo，以i，皤A ofthis isto thecharacteristicvariationin Abstract The P2Xl， Objectivepurposestudy investigate and inratbrainafter boutand exhaustive P2X3，P2X5P2X7 single repeated receptors 68maleSDratsweredivided intothe boutexhaustive repeated randomly single swimminggroup，the the control inthe exhaustive sedentarygroup．Ratsrepeated swimming exhaustingswimminggroup，and fortwoweeks．Thebrain swam with of toexhaustion group everyday 3％bodyweight weight-bearing tissueoftheratswastakenat0 hrand24hrafterexhaustive mRNAlevels hr，4hr，12 swimming．The