吲哚美辛包合物微球的制备和释放研究_王飞.pdfVIP

王飞 , 梁文权( , 310031) : 以吲哚美辛为模型药物研究采用包合物来改善难溶性药物在微球中 释放 吲哚美辛用-环糊精制成 包合物后, 再用海藻酸钠与明胶用复凝聚法制备成微球, 观察其形态, 测定粒径, 包封率, 并以磷酸缓冲液为释放介质, 研究微 球 体外释放, 同时以吲哚美辛微球, 吲哚美辛与-环糊精混合物微球作对照 吲哚美辛--环糊精包合物微球药物释 放速率为0. 25min- 1, 而其他两种微球分别为 0. 14, 0. 16 min- 1 环糊精包合物可以改变吲哚美辛在微球中 释放行 为 : 微球;-环糊精; 包合物; 吲哚美辛; 海藻酸钠; 明胶 : R943. 4 : A : 1007-7693( 2003) 06-0483-03 Studies onpreparationof indomethacin--cyclodextrininclusioncomplexinmicrospheresanditsreleasein vit- ro WANG Fei , LIANG Wen-qu n( College of Pharmaceutical Sciences, Zhej iang University, Hangz hou310031, China) ABSTRACT:OBJECTIVE T o study the bet -cyclodextrin(-CD) inclusion complex regul ting the rele se r te of poorly w ter soluble drugs in the microsphere. ETHOD The inclusion complex composed of indometh cin nd -CD w s prep red nd ch r cterized by differenti l therm l n lysis( DTA) . Indometh cin lone, indometh cin inclusion complex or indometh cin w ith -CD s physic l mix- ture w ere incorpor ted into ngin te-gel tin microspheres by complex co cerv tion technique. microspheres w ere ch r cterized for morphology, di meter , enc psul tion efficiency, nd rele se kinetics. RESULTS The rele se of indometh cin in inclusion complex from t he micropheres is f ster nd more complete. CONCLUSION The microsphere enc psul ting -CD inclusion complex h s gre t potenti l s controlled rele se system bec use it c n improve the rele se beh vior of poorly w ter soluble drugs. KEY WORDS:microsphere; -cy clodextrin; inclusion; indometh cin; lgin te; gel tin , -, 45 , 30min, , , 5h, , , , , , , 60 2h, P O 2 5 -, [ 1~ 3] , 2. 2 2. 2. 1 , -, 1 - 1: 1 4 1. 1 10 , 400 , ( ) ;-(