计算与生物学.ppt

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计算与生物学

Computational Science and Technique in Biological System Professor Tao ZHANG College of Life Science, Nankai University Slide 1 研究背景 神经活动 痴呆、抑郁、孤独症等认知功能改变 突触可塑性 长时程增强LTP 同步与耦合 神经元放电信号PAC的生物学意义 相位幅值耦合可能与很多记忆过程相关 1.海马和前额叶皮层的相位幅值耦合机制可能支持工作记忆。 2.相位幅值耦合也与长程记忆有关 比如,海马中theta_gamma的PAC 在学习联想任务后比学习前更强。 Theta 波 Gamma波 PAC Outline of lectures Introduction Frequency domain analysis Time-frequency analysis Examples of application Time domain analysis Examples of application Experimental Data Analysis Exam Slide 2 Example-1 0.124231 -4.62E-02 4.21E-02 8.05E-02 -0.148692 4.62E-02 9.52E-02 -3.18E-02 7.37E-02 -3.08E-04 4.63E-02 5.05E-02 -5.41E-02 4.45E-02 -0.141231 -0.140462 -6.88E-02 -0.178692 0.128462 -0.283692 -0.164923 -0.156154 -0.124231 0 1.72E-02 1.12E-02 0.112308 2.31E-03 6.38E-02 7.70E-02 -8.91E-02 0.109308 -9.77E-03 -0.243308 -0.174231 -0.164923 0.120154 1.55E-02 3.68E-02 0.101231 -0.135231 7.55E-02 4.93E-02 -0.167 2.97E-02 -0.108 -4.62E-02 -0.193 -0.143923 … Pattern of neural activity Energy distribution in frequency domain (Hz-%Power) Heart rate frequency Respiratory frequency Computational Analysis 1.9723 1.3605 1.0013 1.5462 1.0292 1.6447 0.8043 3.3771 1.3849 1.2942 … 1.1333 0.5097 0.317 0.1124 0.375 0.4691 0.3416 0.1986 0.3072 0.0834 0.2814 8.1844 14.5578 5.6318 0.3203 0.1252 0.1343 0.8465 1.0757 0.1899 0.4942 … Neural Oscillation Synaptic Plasticity Alterations of Cognitive Functions ? Synaptic plasticity is widely believed to provide the cellular basis for most models of learning and memory and point to the important roles in cognitive functions. Neural oscillatory phenomena and their synchronization are related to cognitive processes, with properties changing under cognitive disorders. From animal study it is well known that neural oscillations in the delta and theta frequency bands are the dominant rhythms, and theta oscillations reflect cognitive and memory performance. * Example-2 Neuronal Synaptic Plasticity - The abilit

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