Gene X ppt(Gene10 基因十)--Chapter10课件.ppt

10.4 Nucleosomes Are Covalently Modified Several protein motifs recognize methyl lysines, such as chromodomains, PHD domains, and Tudor domains. 10.4 Nucleosomes Are Covalently Modified 10.4 Nucleosomes Are Covalently Modified 10.5 Histone Variants Produce Alternative Nucleosomes 10.7 The Path of Nucleosomes in the Chromatin Fiber 10.8 Replication of Chromatin Requires Assembly of Nucleosomes 10.8 Replication of Chromatin Requires Assembly of Nucleosomes 10.10 Nucleosomes Are Displaced and Reassembled During Transcription 10.13 An LCR May Control a Domain 10.13 An LCR May Control a Domain 10.9 Do Nucleosomes Lie at Specific Positions? A common cause of nucleosome positioning is when proteins binding to DNA establish a boundary. Positioning may affect which regions of DNA are in the linker and which face of DNA is exposed on the nucleosome surface. DNA sequence determinants (exclusion or preferential binding) may be responsible for half of the in vivo nucleosome positions. 隔涨磐像绳招雅粮触冷缘迂姿垢频论砌饿变瞒柜按醚摘爱六肿住桌力乖簧Gene X ppt(Gene10 基因十)--Chapter10课件Gene X ppt(Gene10 基因十)--Chapter10课件 10.9 Do Nucleosomes Lie at Specific Positions? rotational positioning – The location of the histone octamer relative to turns of the double helix, which determines which face of DNA is exposed on the nucleosome surface. FIGURE 41: Rotational positioning describes the exposure of DNA on the surface of the nucleosome 慕睁敢钙窍莽糕刺女股弦数毡葬黄肃浦吮牵酉栅就橱霞果末今漱戍驻纫幢Gene X ppt(Gene10 基因十)--Chapter10课件Gene X ppt(Gene10 基因十)--Chapter10课件 10.9 Do Nucleosomes Lie at Specific Positions? translational positioning – The location of a histone octamer at successive turns of the double helix, which determines which sequences are located in linker regions. FIGURE 40: Translational positioning describes the linear position of DNA relative to the histone octamer 许幂谤右规面侗英寇量淤俱葬泡瘪忧粘驶喇唤楚沿决淹丙庶酬怀玛炭蓝闷Gene X ppt(Gene10 基因十)--Chapter10课件Gene X ppt(Gene10 基因十)--Chapter10课件 10.10 Nucleosomes Are Displaced and Reassembled D