MRSA的进展.ppt

* * 口服Zyvox 600mg bid 後之血漿便化 * The last case is a patient with acute lymphoblastic leukemia, who received chemotherapy. He developed sepsis due to C. tropicalis during neutropenic state. Fever and chills occurred during fluconazole treatment and culture of the removed catheter grew VRE. Faecium. The patient also had gut VRE colonization. Linezolid was used for a total of 10 days. All these six patients responded well to linezolid treatment and had minimal adverse effect related to linezolid use. * * * * * * * * 利奈唑胺浓度越高，TNF因子的数量越少，有助于减少机体炎性反应。 * 利奈唑胺浓度越高，TNF因子的数量越少，有助于减少机体炎性反应。 * * * * * * * * * * Purpose of slide: To discuss the unique mechanism of action of daptomycin. In viable bacteria, the polarized state of the cytoplasmic membrane results from the maintenance of ion and proton gradients across the bilayer of the plasma membrane. One of the most prominent gradients involves potassium (K+), with high intracellular and low extracellular concentrations. Mechanism of action (MOA) of daptomycin: Step 1: Daptomycin inserts into the cytoplasmic membrane of bacteria. This step is calcium-dependent, as indicated by whole cell and in vitro studies. Step 2: An ion-conduction structure (eg, a channel, pore, or a less structured aggregate) is formed by the oligomerization of inserted drug. This step is hypothetical. Step 3: The ion-conduction structure disrupts the functional integrity of the membrane, resulting in the efflux of intracellular potassium ions. No lag time between membrane depolarization and bacterial killing was found, which strongly suggests that depolarization is the primary MOA. Results of in vitro studies using fluorometry and flow cytometry have shown that the rapid depolarization of the bacterial cell membrane by daptomycin correlates with bactericidal activity. References Data on file. Cubist Pharmaceuticals. Lexington, Mass. Lakey JH, Ptak M. Fluorescence indicates a calcium-dependent interaction between the lipopeptide antibiotic LY146032 and