Suppression of KCNQ-M (Kv7) potassium channels in dorsal root ganglion neurons 骨癌痛.pptx

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2017-08-14 发布于湖北
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Suppression of KCNQ-M (Kv7) potassium channels in dorsal root ganglion neurons 骨癌痛.pptx

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Suppression of KCNQ-M (Kv7) potassium channels in dorsal root ganglion neurons 骨癌痛

Suppression of KCNQ/M (Kv7)potassium channels in dorsal root ganglionneurons contributes to the development of bone cancer pain in a rat model ;background;background;background;background;Materials and Methods;Behavioural studies;Result;Result;Radiological evaluation of tumour growth and bone destruction;Histological evaluation of tumour growth and bone destruction;Increase in excitability of small-sized DRG neurons in bone cancer rats;KCNQ2-positive expression in DRG neurons;KCNQ3-positive expression in DRG neurons;Decrease in expression of KCNQ2/3 inDRG neurons in MRMT-1 rats;Western blotting detection of KCNQ2/3;The density of M currents decreased significantly in MRMT-1;Current-voltage relationship of M currents;Mean instantaneous and steady-state I-V relationships for M currents;inhibition of M currents by XE-992;;effects of XE-991 on M currents and the firing properties of small DRG neurons;effects of retigabine on M currents and the firing properties of small DRG neurons;intraperitoneal administration of XE-991;intraperitoneal administration of retigabine;conclusion