Primary afferent neurons of the gut课件.ppt

Primary afferent neurons of the gut （消化道初级感觉神经元） Function: Monitoring and control of the digestive system, including: Generating appropriate reflex response to the gut lumen contents Participates in reflexes between organs Convey signals from digestive organs to the CNS – Trigger reflex Co-ordination with other body system Relate to sensation including discomfort, nausea, pain and satiety;intrinsic and extrinsic 内源性和外源性;Intrinsic primary afferent neurons, IPANs, within ENS;I Intrinsic Primary Afferent Neurons and Nerve Circuits within the Intestine;Types of neurons that form enteric nerve circuits According to the functions, key transmitters projections to targets ;LM: longitudinal muscle; MP: myenteric plexus; CM: circular muscle; SM: submucosal plexus; Muc: mucosa. ;LM: longitudinal muscle; MP: myenteric plexus; CM: circular muscle; SM: submucosal plexus; Muc: mucosa;2. Characteristics of intrinsic primary afferent neurons (IPANs);2. Characteristics of IPANs- Conti;2. Characteristics of intrinsic afferent neurons- Conti;2. Characteristics of IPANs- Conti;Mucosal mechanoreceptors: Puffs of nitrogen gas on the mucosal induce C-Fos expression in IPAN Blocked by TTX Unaffected by hexamethonium (六甲铵), the nicotinic receptor antagonist Mostly indirect, through the release of 5-HT from enterochromaffin cells (肠嗜铬细胞) in the mucous membrane (粘膜);3. Enteric nerve circuits Intrinsic reflexes that affect motility, water and electrolyte secretion and blood flow all occur in the intestine Circuits for motility control;Secretomotor and vasomotor reflexes;II Extrinsic Primary Afferent Neurons The rich sensory innervation (神经支配) of the gastrointestinal tract comprise: Intrinsic sensory neurons contained entirely within the gastrointestinal wall Intestinofugal fibres 肠离心神经纤维 that project to prevertebral ganglia (椎前神经节) Vagal and spinal afferent that projects to the central nervous system. ;埃妥拒钧餐靖挝品鸦抒统台奈家冶暗拨业薪砾幻热镭汕雍囤扳喉歼豺碱打Primary afferent neurons of the gut课件Primary afferent