慢性肾小球肾炎患者尿一氧化氮代谢产物测定及临床意义初步研究.docVIP

慢性肾小球肾炎患者尿一氧化氮代谢产物测定及临床意义初步研究 陆文 王一平 【摘要】 目的：我们测定慢性肾小球肾炎患者尿中No代谢产物的排泄，以了解慢性肾小球肾炎患者肾组织内No合成是否降低。方法：参照Rosslli和Green测定。结果：1.慢性肾炎有高血压组尿中No代谢产物与对照组和无高血压组尿中No代谢产物比较均明显降低p0.01；慢性肾炎无高血压组尿中No代谢产物与对照组比较，无统计差异P0.05。2.MsPGN和FSGS组尿中No代谢产物明显低于对照组和MN、MCD组P0.01，而MN、MCD与对照组比较无差异P0.05。结论：慢性肾小球肾炎合并高血压时尿中No/Cr明显降低，提示肾组织内No的产生可能不足，补充L-精氨酸会对其有利，这也许是测定肾小球肾炎患者尿中Nox-/Cr比值的临床意义所在。 【关键词】 慢性肾小球肾炎 一氧化氮 MEASUREMENT AND CLINICAL SIGNIFICANCE OF NITRIC OXIDE METABOLITES IN CHRONIC GLOMERUL ONEPHRITIS PATIENT’S URINE Lu wen，Wang yi ping. Bao Shan,Shu guang Hospitail Branch, 201900 【Abstract】Objective: No(Nitri Oxide)metabolites in chronic glonerulonephritis patient’s urine were examined to know the synehase of No in patient’s kidney.Method:reffer to Rosslli and Green method.Result:1.The synthase of No metalites in the urine form chronic glomerulonephritis patient with hypertension is significantly reduced(p0.01)comparing with the synthase in control or in non-hypertension.the synthase in non-hypertension has no significant difference (p0.05)comparing with contol.2.The synthase of No metabolites in either MsPGN group or FSGS group is significantly reduced(p0.01) comparing respectively with the synthase in control or MN、MCD group.Whereas the comparison of MN、MCD with control shows no significanl difference (p0.05).Result ：The ratio of No/Cr in chronic glomerulonephritis with hypertension of No synthase in urine is significantly reduced .Supplement L-arginine would be pro baly helpful. This is might be the singnifience of examining the ratio of Nox-/Cr in chronic glomerulonephritis patient’s urine. 【Key】: Chronic glomerulonephritis No 慢性肾脏疾病进展机制及如何延缓、阻止甚至逆转慢性肾脏疾病肾功能进行性损害是目前肾脏病领域研究的热点课题之一。肾小球系膜过度增值和过度合成细胞外基质或者细胞外基质降解减少是肾小球硬化的病理基础。目前所知，肾小球系膜细胞增殖和合成细胞外基质受许多因素的调控，特别是近几年来研究发现一氧化氮(No)参与对肾小球系膜细胞的调控作用。本文测定了肾小球肾炎患者尿中No代谢产物的排泄，并对其临床意义作了初步讨论。 病例和方法 病例选择 1.正常对照组 选择正常志愿患者30名，其中男性14名，女性16名，平均年龄41+8岁，无高血压、尿路感染和慢性肾脏疾