注射用头孢西丁钠（Cefoxitin sodium for Injection）.docVIP

注射用头孢西丁钠（Cefoxitin sodium for Injection） 注射用头孢西丁钠（注射用头孢西丁钠） 本品主要成份为头孢西丁钠，其化学名称为：（6R，7S）3 [（1氨甲酰氧）甲基] - 7 -甲氧基- 8 -氧代7 [ 2（2噻吩基）乙酰氨基] - 5 -硫杂- 1 -氮杂双环[4.2.0]辛- 2 - 2 -甲酸钠盐烯。 【性状】 本品为白色或类白色粉末。 【药理毒理】 注射用头孢西丁钠通过抑制细菌细胞壁合成而杀灭细菌，且由于本品结构上的特点使其对细菌产生的β－内酰胺酶具有很高的抵抗性，下列临床常见革兰氏阳性、阴性需氧及厌氧致病菌对本品高度敏感。 需氧菌厌氧菌 革兰氏阳性球菌革兰氏阳性球菌 －葡萄球菌（包括凝固酶阳性、－肠球菌 阴性和产青霉素酶的菌株）－粪链球菌 －一组乙型溶血性链球菌－微需氧链球菌 －B组乙型溶血性链球菌 －肺炎链球菌革兰氏阳性杆菌 －其它链球菌中D组链球菌－产气荚膜梭状芽胞杆菌 革兰氏阴性球菌－梭状芽胞杆菌 －淋病（奈瑟氏）球菌－真杆菌 －脑膜炎（奈瑟氏）菌－痤疮丙酸杆菌 革兰氏阴性杆菌革兰氏阴性球菌 －大肠杆菌－韦容氏球菌 －肺炎克雷白杆菌 －克雷白杆菌属尚有下列革兰氏阴性菌 －奇异变形杆菌－脆弱拟杆菌 －变形杆菌（吲哚阳性）－黑色素拟杆菌 普通变形杆菌－类杆菌（包括青霉素敏感和青霉素耐药菌株） 摩根变形杆菌 －流感（嗜血）杆菌－梭杆菌 －粘质沙雷氏菌 －普鲁威登菌 －沙门氏杆菌及志贺氏菌 注射用头孢西丁钠对下列细菌敏感度视菌株需作药敏试验而定。 －不动杆菌属硝酸盐阴性杆菌－粪产碱杆菌 －枸橼酸杆菌－肠杆菌 注射用头孢西丁钠对绿脓杆菌、肠球菌大多数菌株，阴沟杆菌等耐药。 【药代动力学】 正常志愿者肌内注射1g后，20－30分钟血药浓度达峰值为24μμg／mL，静注1g后， 5 minutes of blood concentration reached the peak of 110 g/ml, 4 hours after the blood concentration of less than 1 g/ml. After intravenous injection the half-life for 41-59 minutes after intramuscular injection of this product has a half-life of 64.8 minutes. After 6 hours, about 85% of drugs in the original excretion by the kidneys and urine after intramuscular injection of the 1g, peak concentration can reach more than 3000 mu g/ml. This product is widely distributed in the body, after the administration can quickly enter the various body fluids, including hydrothorax, ascites, bile, cerebrospinal fluid but the penetration rate is low, the binding rate of protein was 80.7%. Cefoxitin Sodium for Injection is mainly from the prototype of renal excretion, renal clearance including glomerular filtration and renal tubular excretion, 6 hours after administration of the equivalent to 85% dose excreted by kidney from urine, plasma elimination half-life of 1 hours. [indications] The following applies to infection caused by bacteria sensitive of this product: The upper and lower respiratory tract infection Urinary tract infection (including uncomplicated gonorrhea) Peritonitis and other abdominal and pelvic infection