第三章 药动学（The third chapter is pharmacokinetics）.docVIP

第三章 药动学（The third chapter is pharmacokinetics） The third chapter is pharmacokinetics The third chapter is pharmacokinetics The main point of the pre exam counseling is my last years study notes, and also this years division of my pharmacists examination, pharmacology, test preparation, lecture notes, and Im sure there is a mistake. Please correct me!! The rebound will be time-consuming in January 2003, please quote the source. Master the uptake and distribution of drugs and its effects, P450 enzymes and inhibitors and inducers, drug excretion pathway and its influencing factors of renal excretion, plasma protein binding rate and the concept of enterohepatic circulation. Pharmacokinetics, referred to as pharmacokinetics, studies the processes in vivo and in vivo concentrations of drugs over time. The distribution of drugs in vivo is balanced, and the pharmacological effect is proportional to the plasma concentration of drugs. The doctor can calculate the dosage of the drug according to the regularity of the pharmacokinetics so as to reach the required blood concentration and grasp the potency of the medicine for a long time. Better results than empirical prescriptions alone. Section 1 drug in vivo process I. trans membrane transport of drugs The process of drug absorption in vivo: absorption, distribution, biotransformation and excretion, the process of trans membrane transport is absorption, distribution and excretion. 1, passive transport (CIS gradient transport) drugs rely on the concentration difference between the two sides of the membrane, from one side of the high concentration to the low side of the process of diffusion and transport. Most drugs are passive transporters. (1) characteristics: no carrier, no energy consumption, no saturation phenomenon and competitive inhibition. (2) the factors affecting the diffusion velocity: The drug concentrations on both sides of the membrane were poor. Drug physical and chemical properties: small molecular weight, fat so