中国13城市新生儿先天性甲状腺功能减低症发病率分析研究.pdfVIP

索庆丽等 中国13城市新生儿先天性甲状腺功能减低症发病率分析研究 第5期 · 673· · 调查研究· 中国13城市新生儿先天性甲状腺功能减低症发病率分析研究 索庆丽 胡唏江 湖北省武汉市妇女儿童医疗保健中心 430015 中国图书分类号 11722．1．R581．2 文献标识码 A 文章编号 1001-4411(2008)05-06734)3 【摘 要】 目的：通过13城市新生儿CH筛查情况，总结中国主要城市和地区先天性甲状腺功能减低症 (Congenital Hypo． thyroidism，CH)发病率，寻找规律，探讨对策。方法：筛查对象为出生72 h后的新生儿，采足跟末梢血制成干血滤纸片，用 FEIA法、EIA法、ELISA法或DELFIA法检测干血片中TSH含量，将初筛阳性儿召回确诊。结果：13城市共对3 351 818例新生 儿进行了CH筛查，确诊CH患儿975例，CH发病率为0．291qt~，总体来看，中国北部和南部地区CH发病率低于东部、中部和 西部地区。讨论：CH高发病率地区和城市要认真研究本地区CH发病的主要原因，有针对性地采取预防措施，降低CH发病率， 同时，对初筛阳性儿，在诊断时要注意高TSH血症儿的误诊问题。CH低发病率地区和城市要审视标本采集、递送、实验室质量 和诊断等各环节，以避免漏检和漏诊。 【关键词】 新生儿 先天性甲状腺功能减低症 发病率 分析 Analysis and study of morbidity rates of newborn congenital hypothyroidism at 1 3 cities in China SUO Qing—Li，HU Xi—Jiang．Wuhan Women and Children Medical Care Center，Wuhan 430015，Hubei，China (Abstract] Objective：By screening congenital hypothyroidism(CH)data of 13 cities newborn baby to sulnmarlze the main city and area CH morbidity rates and analy~ the difference causes and countermeasures．Methods：A drop of plant~ blood was obtained from newborns 72 hours after delivery to dry onto a filter paper to test blood levels of TSH with FEIA，EIA，ELISA or DELIRIA method．Screened positive Cases were called back for futher diagnosis．Results：Among the screened 3 351 818 cases in 13 cities，975 cases were diagnosod as CH，CH morbidity rate Was 0．291qt~．Overall CH morbidity rate in northern and southern of China Was lower than that in eastern，middle and western 8I~L Conclusion：The higher CH morbidity rate areas and the cities should study the main reasons which cause hish local CH morbidity rate and take preventive measures to reduce CH morbidity rote．However，the screen positive cases with hisher TSH blood level must be paid attention to and be surely not to be misdiagnosod．The lower morb