孕前补充小剂量叶酸预防胎儿NTD临床探析.docVIP

孕前补充小剂量叶酸预防胎儿NTD临床探析【中图分类号】R715 【文献标识码】B 【文章编号】1672-6383(2010)11-0069-01 【摘要】目的:探讨孕前补充小剂量叶酸(斯利安或福施福)在预防胎儿NTD的临床意义。方法:濮阳市计划生育指导中心及濮阳市妇幼保健院2007年12月31日~2009年12月31日收集全市各区领取生育证的60000例待孕妇女中成功受孕者中随机抽取50000例,并于孕前3个月至孕后前3个月每日增补400ug叶酸,与50000例孕妇未服用叶酸者组成对照组,进行孕期彩超产前筛查及尸解结果进行分析。结果:待孕妇女妊娠前后单纯服用400ug叶酸片,可以降低NTD的发生,预防率达到86%以上。结论:待孕妇女孕前3个月至孕后3个月末每日增补400ug叶酸(北大药业提供),可有效降低胎儿NTD的发生,达到优生优育的目的,进一步提高我市出生人口素质。 【关键词】 NTD;叶酸;待孕妇女 Before the Yun complement small quantity folic acid prevention embryo NTD clinical study Wang Dongjiao?1 ChenWenzhuo? 1 LiXueguang?2Li Ya Min? 2 【Abstract】Purpose:Study before the Yun complement small quantity folic acid(the Si benefit Anne or blessing Shi Fu2) at prevention embryo NTD’s clinical meaning.Method:The Pu planned parenthood in the sun City instruction center and the Pu Fu in the sun City young health care hospital 2007 December 31 day~2009 December 31 day collections each area of whole city receive 60000 of grow the certificate to need a pregnant woman female medium success conceive medium random sample 50000, and in Yun ex-3 months go to Yun empress ex-3 months everyday increase to repair a 400 ug folic acid, have never taken a folic acid with 50000 pregnant woman to constitute a matched control, carry on Yun period colourful super prenatal period Shai to check and corpse solution result carry on analysis.Result:Need a pregnant woman a female gestation in front and back pure take the 400 ug folic acid slice, can lower NTD of occurrence, prevent rate from attain above 86%.Conclusion:3 after needing a pregnant woman a female before the Yun for 3 months to the Yun the end of month everyday increase to repair a 400 ug folic acid(north the big medicine industry provide), can valid lower embryo NTD of occurrence, attain excellent living excellent teach of purpose, further exaltation my city birth population character. 【Key words】NTD;Folic acid;Need a pregnant woman a female 1.材料和方法 1.1 研究对象:收集2007年12月31日~2009年12月31日间濮阳市高新区、华龙区的孕龄妇女:第