水通道蛋白5在乳腺浸润性导管癌中表达及与肿瘤转移之间的关系_姜廷枢.pdf

24 3 ·229 · ·　 · 5 1 2 3 4 1 姜廷枢,赵恒成 ,张　红 ,徐德魁 ,李胜岐 　　〔〕　:探讨水通道蛋白5 在乳腺浸润性导管癌组 中的表达与分布及与乳腺浸润性导管癌组 学分级和 转移之间的关系。:采用免疫组 化学方法, 对90 例乳腺浸润性导管癌组 及作为对照的癌旁组 中水通道蛋白 表达情况进行检测, 并与淋巴结转移和组 学分级进行分析。:水通道蛋白5 主要表达于正常乳腺和癌组 细胞膜 和细胞浆中。组 学分级Ⅲ级癌组 水通道蛋白高表达率明显高于组 学分级Ⅰ级和Ⅱ级患者;淋巴结转移的乳腺癌 组 中水通道蛋白5 高表达率明显高于无淋巴结转移者。:水通道蛋白5 可能在乳腺癌肿瘤形成和发展过程中起 重要作用,有望成为预测乳腺癌转移和评估预后的重要指标和治疗靶点。 　　〔〕　乳腺癌;水通道蛋白5;肿瘤转移 　　:R737.9　　:A 　　:1674-3474(2010)03-0229-02 Expression of aquaporin 5 in breast infiltrating duct carcinoma and its correlation with tumor metastasis JIANG Tingshu, ZHAO Hengcheng, ZHANG Hong, et al. epartment of Respiratory, Shengjing Affiliated Hospital to China Medical University, Shenyang 110004, China 　　〔Abstract 〕Obj ective To study the expression and distribution of aquaporin 5 in breast infiltrating duct carcinoma and to analyze its correlation with pathological grades and metastasis.Methods SP immunochemical method was used to detect the expression of aquaporin 5 in the tissues of 90 patients with breast infiltrating duct carcinoma.The pathological grades and metastasis factors were statistically analyzed.Results Aquaporin 5 was mainly expressed in cell membrane, cytoplasm of normal breast ductal epithelial cells and cancer cells.T he high expression rate of aquaporin 5 was higher in cells of breast carcinoma histological stage Ⅲ than that in stage Ⅰ and Ⅱ, and increased significantly in patients with lymphatic metastasis.Conclusion Aquaporin 5 expression may play an important role in the breast carcinogenesis and progression.The expression of aquaporin 5 can be taken as the biological marker of prognosis and metastasis and be used as a target of therapies fo