概念抗原递呈细胞.ppt

胞质溶胶（MHC-I类分子途径） 内源性抗原被胞质溶胶中蛋白酶体降解为小分子抗原肽后，与 MHC-I类分子结合，形成抗原肽/ MHC-I类分子复合物，供CD8+T细胞识别的过程。如病毒抗原、肿瘤抗原，组织抗原等主要经此途径递呈。 Degradation in the proteasome The components of the proteasome include MECL-1, LMP2, LMP7 These components are induced by IFN-g and replace constitutive components to confer proteolytic properties. LMP2 7 encoded in the MHC Proteasome cleaves proteins after hydrophobic and basic amino acids and releases peptides into the cytoplasm Cytoplasmic cellular proteins, including non-self proteins are degraded continuously by a multicatalytic protease of 28 subunits Degradation