原创力文档胞质溶胶类分子途径内源性抗原被胞质溶胶中蛋白酶体降解为小分子抗原肽后与类分子结合形成抗原肽类分子复合物供细胞识别的过程如病毒抗原肿瘤抗原组织抗原等主要经此途径递呈内源性抗原递呈的类分子途径内源性抗原递呈途径内源性抗原如病毒抗原肿瘤抗原胞质被蛋白酶体酶解抗原肽含个经转运至内质网形成抗原肽类分子复合物转运至表面递呈给细胞识别概念抗原递呈细胞抗原递呈胞质溶胶途径溶酶体途径分子递呈途径主要内容外源性抗原被摄取加工处理为抗原肽与类分子形成抗原肽类分子复合物表达于表面供细胞识别的过程溶酶体类分子途径授课教师
胞质溶胶（MHC-I类分子途径） 内源性抗原被胞质溶胶中蛋白酶体降解为小分子抗原肽后，与 MHC-I类分子结合，形成抗原肽/ MHC-I类分子复合物，供CD8+T细胞识别的过程。如病毒抗原、肿瘤抗原，组织抗原等主要经此途径递呈。 Degradation in the proteasome The components of the proteasome include MECL-1, LMP2, LMP7 These components are induced by IFN-g and replace constitutive components to confer proteolytic properties. LMP2 7 encoded in the MHC Proteasome cleaves proteins after hydrophobic and basic amino acids and releases peptides into the cytoplasm Cytoplasmic cellular proteins, including non-self proteins are degraded continuously by a multicatalytic protease of 28 subunits Degradation
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