微小rna-200家族对糖尿病及其并发症的影响-中华老年多器官疾病.docVIP

·综 述· 微小RNA-200家族对糖尿病及其并发症的影响 钱玲玲，徐 凤，王如兴* （南京医科大学附属无锡市人民医院心内科，无锡 214023） 【摘 要】糖尿病并发症可引起人体心、脑和肾等重要组织和器官损害，严重危害人类健康，但其发病机制并不十分清楚。近年研究发现微小RNA（microRNA）在糖尿病及其并发症的发生发展中起重要作用。microRNA是真核生物中一类长度在22～25个核苷酸左右的内源性非编码小分子RNA，通过转录后机制调控其下游靶基因的表达，进而影响疾病的病理生理学过程。其中microRNA-200（miR-200）家族对糖尿病及其并发症的调控研究较多。MicroRNA-200（miR-200）家族不仅对胰岛素相关信号通路具有调控作用，在糖尿病微血管及大血管并发症中也发挥重要调控作用。因此，探讨miR-200家族与糖尿病及其并发症之间的关系，可为糖尿病及其并发症的诊断及治疗提供新的思路。 【关键词】微RNAs；miR-200；糖尿病；并发症 【中图分类号】 R342.3; R587.1 【文献标识码】 A 【DOI】 10.11915/j.issn.1671-5403.2015.xx.xxx Role of microRNA-200 family in diabetes mellitus QIAN Ling-Ling, XU Feng, WANG Ru-Xing* (Department of Cardiology, Wuxi People’s Hospital Affiliated to Nanjing Medical University, Wuxi 214023, China) 【Abstract】 The complications of diabetes usually cause target organ damage, such as the heart, brain, kidneys and others, and are seriously hazardous to human health. But the underlying mechanism is still not very clear. Recent studies indicated that microRNA (miRNA) plays an important role in the occurrence and development of diabetes and its complications. miRNA, an endogenous small non-coding RNA molecule (containing about 22-25 nucleotides) in eukaryotes, regulates the expression of its downstream target genes at post-transcriptional level, and then influences the pathophysiology of diseases. There are many studies have reported that microRNA-200 (miR-200) family plays certain regulative roles in diabetes and its complications. The family not only regulates insulin related signal pathway, but also plays an important role in diabetic microvascular and macrovascular complications. Therefore, to explore the relationship of miR-200 family with diabetes and its complications would provide a new train of thought for diagnosis and treatment of diabetes and its complications. 【Key words】 microRNAs; miR-200; diabetes mellitus; complications This work was supported by the National Natural Science Foundation of China , the Natural Scien