促肾上腺皮质激素释放激素及其受体与动脉血压与心率关系.docVIP

促肾上腺皮质激素释放激素及其受体与动脉血压和心率的关系！1: HYPERLINK javascript:AL_get(this,%20jour,%20Am%20J%20Physiol%20Heart%20Circ%20Physiol.); Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H325-32. Epub 2008 Dec 5. HYPERLINK javascript:PopUpMenu2_Set(Men; \t _self Links Cardiovascular responses to microinjections of urocortin 3 into the nucleus tractus solitarius of the rat. HYPERLINK /sites/entrez?Db=pubmedCmd=SearchTerm=%22Nakamura%20T%22%5BAuthor%5Ditool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus Nakamura T, HYPERLINK /sites/entrez?Db=pubmedCmd=SearchTerm=%22Kawabe%20K%22%5BAuthor%5Ditool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus Kawabe K, HYPERLINK /sites/entrez?Db=pubmedCmd=SearchTerm=%22Sapru%20HN%22%5BAuthor%5Ditool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus Sapru HN. Department of Neurological Surgery, UMDNJ-New Jersey Medical School, Newark, NJ, USA. Urocortin 3 (Ucn3) is a new member of the corticotropin-releasing factor (CRF) peptide family and is considered to be a specific and endogenous ligand for CRF type 2 receptors (CRF2Rs). The presence of CRF(2)Rs has been reported in the nucleus tractus solitarius (NTS) of the rat. It was hypothesized that the activation of CRF2Rs in the medial NTS (mNTS) may play a role in cardiovascular regulation. This hypothesis was tested in urethane-anesthetized, artificially ventilated, adult male Wistar rats. Microinjections (100 nl) of Ucn3 (0.03, 0.06, 0.12, and 0.25 mM) into the mNTS of anesthetized rats elicited decreases in mean arterial pressure (MAP: 5.0 +/- 1.0, 21.6 +/- 2.6, 20.0 +/- 2.8, and 12.7 +/- 3.4 mmHg, respectively) and heart rate (HR: 7.8 +/- 2.6, 46.2 +/- 9.3, 34.5 +/- 8.4, and 16.6 +/- 4.9 beats/min, respectively). Microinjections of artificial cerebrospinal fluid (100 nl) into the mNTS did not elicit cardiovascular responses. Maximum decreases in MAP and H