蚕丝丝素蛋白,壳聚糖支架在骨科再生医学中的作用与特点.docVIP

蚕丝丝素蛋白/壳聚糖支架在骨科再生医学中的作用与特点 袁振中，陈跃平(广西中医药大学附属瑞康临床医学院，广西壮族自治区南宁市 530011) 引用本文：袁振中，陈跃平. 蚕丝丝素蛋白/壳聚糖支架在骨科再生医学中的作用与特点[J].中国组织工程研究，2017，21():2280-2284. DOI:10.3969/j.issn.2095-4344.2017.14.024 ORCID: 0000-0002-7024-2799(陈跃平) 文章快速阅读： 文题释义： 蚕丝丝素蛋白/壳聚糖支架的性能：广西高校青年教师基础能力提升项目(KY2016YB204)；广西中医药大学校级科研项目(2015LX027)；2014年广西中医药大学校级培育学科-骨外科学建设项目[J13167(7)] Application and characteristics of silk fibroin/chitosan scaffold in orthopaedic regenerative medicine Yuan Zhen-zhong, Chen Yue-ping (Ruikang Clinical College, Guangxi University of Chinese University, Nanning 530011, Guangxi Zhuang Autonomous Region, China) Abstract BACKGROUND: A silk fibroin/chitosan scaffold has good biocompatibility, osteoinductivity and degradability. OBJECTIVE: To review the structure, performance and application of the silk fibroin/chitosan scaffold in bone, cartilage and soft tissue engineering regeneration. METHODS: PubMed, Wanfang, and CNKI databases were retrieved by computer for articles related to the structure, performance and application of the silk fibroin/chitosan scaffold in orthopedics published from 1998 to 2016. The keywords were “chitosan, silk protein, bone tissue engineering” in English and Chinese, respectively. RESULTS AND CONCLUSION: The silk fibroin/chitosan scaffold is characterized by good biocompatibility, bone inductivity and biodegradability that make cells grow well on the scaffold. The silk fibroin/chitosan scaffold has been widely used in bone tissue engineering, and has a prominent performance in bone defect repair and cartilage injury treatment. Meanwhile, the silk fibroin/chitosan scaffold exerts a crucial role in wound healing as well as in the treatment of spinal nerve injury and other soft tissue injuries. However, the silk fibroin/chitosan scaffold currently is less reported in the clinical use due to various reasons, and it will be the main research direction of future efforts. As is known to us, silk protein can be used to prepare the cruciate ligament a