阴道微生态与高危型人乳头瘤病毒感染和宫颈病变的相关性研究.docVIP

阴道微生态与高危型人乳头瘤病毒感染和宫颈病变的相关性研究 　　摘要：目的 研究分析阴道微生态与高危型人乳头瘤病毒（HPV）感染和宫颈病变的相关性。方法 将2014年9月～2016年9月于我院进行妇科检查的280例患者作为研究对象，对其分别进行宫颈液基细胞学检测、高危HPV检测及阴道环境判定，所得结果与手术病理及临床证实结果进行分析，比较两种诊断的准确率。结果 280例体检女性中，高危型HPV感染者62例（21.14%），无HPV感染者218例（77.86%），HPV16型、HPV、HPV18型、混合感染人数分别为21、18、23例，感染类型差异无统计学意义（P0.05）；280例体检女性中，宫颈病变者70例（25.00%），宫颈正常者210例（75.00%）；阴道微生态中，乳酸杆菌、念珠菌及阴道清洁度与高危型HPV感染和宫颈病变的发生有密切关系，差异有统计学意义（P0.05）。结论 乳酸杆菌、念珠菌及阴道清洁度等阴道微生态指标都是造成高危型HPV感染和宫颈病变的相关因素，保证阴道微生态环境的平衡，是预防各类妇科疾病发生的关键。 　　关键词：阴道微生态；高危型HPV感染；宫颈病变；相关性 　　Abstract：Objective To study the vaginal microecology and high-risk human papillomavirus （HPV） infection and cervical lesions.Methods 280 cases of the September 2014 ～2016 year in September in our hospital for gynecological examination of patients as the research object，respectivelyexamined cervical liquid based cytology test and high risk HPV test and vaginal environment determination，income with the results of surgery and pathology confirmed the results of the analysis，comparison of two diagnostic accuracy.Results 280 cases of healthy women，high-risk HPV infection in 62 cases （21.14%），218 cases without HPV infection（77.86%），HPV16，HPV，HPV18，the number of mixed infection were 21，18，23 cases.There was no significant difference between infection type（P0.05）；280 healthy women，70 cases of cervical lesions（25.00%），210 cases of normal cervical（75.00%）；Lactobacillus vaginal microecology，candida，and vaginal cleanliness and high risk HPV There is a close relationship between the occurrence of infection and cervical lesions，the difference was statistically significant（P0.05）.Conclusion Lactic acid bacteria，candida and vaginal cleanliness and vaginal micro ecological indicators are the factors causing the high-risk HPV infection and cervical lesions，to ensure the balance of the vaginal micro ecological environment，is the key to prevent various gynecological diseases happen. 　　Key words：Vaginal microecology；High-risk HPV infection；Cervical lesions；Correlation 　　宫颈癌是一种常见的妇科恶性肿瘤疾病，可