MolecularDockingandSp_省略_Acetylgliotoxin.pdfVIP

2010, Vol.15 No.5, 444-448 Article ID 1007-1202(2010)05-0444-05 DOI 10.1007/s11859-010-0681-z Molecular Docking and Spectroscopic Methods to Probe the Interaction of Acetylgliotoxin and HSA □ ZHANG Lianru, CHEN Junjie, SONG Siyang, 0 Introduction ZHENG Zhonghui, HUANG Yaojian School of Life Sciences, Xiamen University, Xiamen 361005, Acetylgliotoxin was primarily separated from Fujian, China Gliocladium fimbriatum and with strong bioactivity[1]. Interest in acetylgliotoxin as a therapeutic agent was in- © Wuhan University and Springer-Verlag Berlin Heidelberg 2010 itiated when it was shown to prevent viral RNA replica- tion, via inhibition of reverse transcriptase, and also as Abstract: The interaction between acetylgliotoxin and human [2] serum albumin (HSA) has been studied by spectroscopic method. the inhibitor of farnesyl-protein transferase . Further Acetylgliotoxin quenches the intrinsic fluorescence of HSA in a research proved that acetylgliotoxin exhibits a diverse static quenching procedure. The binding of acetylgliotoxin to HSA array of biologic effects, including inhibition of fungi, causes a slight conformational change of HSA. The binding con- bacteria, and viruses[3]. However, the drug usage of ace- stants a