2dna的复制、转录（Replication and transcription of 2dna）.docVIP

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2dna的复制、转录（Replication and transcription of 2dna）.doc

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2dna的复制、转录（Replication and transcription of 2dna）

2dna的复制、转录（Replication and transcription of 2dna） (3) responsible for glycosidase repair of oxidative DNA damage (such as Fpg / MutM DNA glycosylase) BER is the repair of endogenous DNA damage (spontaneous hydrolysis, alkylation and active oxygen attack) the main way, so as to reduce the frequency of spontaneous mutation, has an important role to prevent the tumorigenesis. Two, nucleotide excision repair (Nucleotide excision, repair, NER) First by the poly recognition complex injury, and then removed in damage on both sides. With the DNA chain was solved, including release of single chain fragment injury, fill the gap left by DNA polymerase, DNA ligase closed. The approach includes more than 20 kinds of protein, can repair the radiation induced cyclobutane pyrimidine dimer two ultraviolet (CPD) and (6-4) photoproduct ((6-4) PPs), and had some compounds to produce chemicals. The NER system related gene and its protein product function. The NER system defects and xeroderma pigmentosum (Xeroderm pigmentosum XP) NER can be divided into two sub channels: (1) whole genome repair (Global Genomic repair, GGR): the way to repair the entire genome damage, its efficiency depends on the chemical properties, to damage parts of the DNA sequence and chromatin structure. (2) transcription coupled repair (Trancsription-coupled repair, TCR): specific repair with transcription activity in the genome (the expression) of the gene is transcribed DNA strand damage on the character of this approach is RNA dependent transcription polymerase II catalytic subunit, proteins is a common transcription factor TFIIH. Three, mismatch repair (Mismatch repair) Due to misincorporation responsible for repair of DNA mismatch in replication. STR sequence copy - chain slide template to create small annular projection (loop) - repeat expansion (expansion) or missing: microsatellite instability (microsatellite instability) MMR E coli in the way the need for mutS, mutH, mutL and uvrD gene products and specif