7 生物氧化（7 biological oxidation）.docVIP

7 生物氧化（7 biological oxidation） The seventh chapter biological oxidation The concept and characteristics of the biological oxidation: Oxidizing substances in organism decomposition and energy release process is called biological oxidation. And in vitro combustion, biological oxidation is a consuming O2, generation of CO2 and H2O, and the release of large amounts of energy. But in combustion is different, the bio oxidation process is at 37 degrees, nearly neutral aqueous environment, by enzyme catalytic reaction; gradually release energy, a considerable part of the energy stored in the form of high energy phosphate bond. Two, mitochondrial respiratory chain: In the mitochondria, is composed of a plurality of hydrogen carrier or delivery of electronic body according to a certain sequence consisting of a chain reaction system is related to the cell respiration process called respiratory chain. The delivery of hydrogen or delivery of electronic body often exists in the inner mitochondrial membrane to form complex. The main complex: 1. complex I (NADH- quinone reductase): a molecular NADH reductase (FMN), two molecules of iron sulfur protein (Fe-S) and one molecule of CoQ, its role is to be passed to the CoQ (NADH+H+). Iron sulfur protein molecules containing non heme iron and acid labile sulfur. Iron ions and sulfur atoms in the molecule form a special tetrahedron structure, known as the iron sulfur center or iron sulfur clusters, iron sulfur protein is a single electron transfer. Ubiquinone (CoQ) is a kind of fat found in mitochondrial soluble quinones. Molecules containing benzoquinone structure, can accept two hydrogen atoms into hydroquinone structure, is a kind of double hydrogen carrier. 2. complex II (succinate ubiquinone reductase): a molecule of succinate dehydrogenase (FAD), two molecules of iron sulfur protein and two Cytb560 molecular composition, its role is to pass a FADH2 to CoQ. Cytochrome: This is a kind of iron porphyrin prosthetic group protein, single