丹红注射液对高脂血症疗效的Meta分析.docVIP

丹红注射液对高脂血症 李刚松省人民医院内科成都， 2四川省人民医院内科肾脏病研究所成都， 3电科科技大学院成都，血症加心血管疾病的风险，目前治疗不。研究提示在常规降脂治疗的基础上，加用丹红注射液可以进一步血脂紊乱脂血症Hyperlipidemia LI Gang 1，3 REN Song 2，3 1 Department of Cardiology, Sichuan Provincial People’s Hospital, Chengdu 610072 2 Renal Department and Institute of Nephrology, Sichuan Provincial People’s Hospital, Chengdu 610072 3 School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072 Abstract: Background and Objective Hyperlipidemia can increased the risk of individual cardiovascular disease (CVD), while the therapeutic?effect is not ideal. Previous studies have suggested on the basis of traditional lipid-lowering therapy, combination with Danhong Injection could plus additional effect on dyslipidemia. In this study, the effect of Danhong Injection on hyperlipidemia was analyzed by meta-analysis. Methods By searching on?China?National?Knowledge?Infrastructure(CNKI), Wanfang database, VIP database and pubmed database, all the randomized controlled trials of Danhong Injection on hyperlipidemia were collected. These data were collected from the beginning of building those database to March, 2015. On the basis of the Cochrane systematic review method, the quality of the research literature was evaluated. At the same time, valid data can be collected or extracted for the meta-analysis through using Revman5.3 Software. Result Total 10 randomized controlled trials were involved in the meta-analysis. The results showed that beyond the traditional lipid-lowering therapy, combination with Danhong Injection could further increase the level of high-density lipoprotein by 0.19mmol/L (Z=8.32, P0.001, 95%CI: 0.14~0.23), and further decrease the level of total cholesterol by 0.77mmol/L (Z=10.99, P0.001, 95%CI: -0.91~-0.64), decrease the level of triglyceride by 0.39mmol/L (Z=7.61, P0.001, 95%CI: -0.49~-0.29), decrease the level of low-density lipoprotein by 0.35mmol/L (Z=7.90, P0.001, 95%CI: -0.44~-0.26). Conclusion Beyond the traditional