中药周期性阶段疗法治疗肝肾阴虚型黄褐斑疗效观察.doc

中药周期性阶段疗法治疗肝肾阴虚型黄褐斑疗效观察[摘要]目的：观察中药周期性阶段疗法治疗黄褐斑的临床疗效。方法：将123例患者随机分为两组，治疗组62例，采用月经后服用补精血颗粒与月经前及经期服用理气养血活血颗粒的周期性阶段治疗；对照组61例，采用补精活血颗粒的持续性给药治疗，2个疗程后判定临床疗效。结果：总有效率治疗组为95.08%，对照组为93.22%，两组比较差异无统计学意义（P＞0.05）。结论：两组临床疗效相当，均能有效治疗黄褐斑。 [关键词]黄褐斑；周期性阶段疗法；肝肾阴虚型；中药疗法 [中图分类号]R758.4+2 [文献标识码]A [文章编号]1008-6455（2011）03-0477-02 Clinical study of the treatment effect of the therapy of periodical phase of Chinese Medicine on melasma LI Zhen-jie,LIN Chun-sheng,DENG Jing-hang,LI Yan-hong,YE Xing-dong，ZHU Hui-lan (Guangzhou Institute of Dermatology and Venereology, Guangdong，Guangzhou 510095, Guangdong,China) Abstract：ObjectiveTo evaluate the treatment effect ofperiodical phase of Chinese Medicine on Melasma. Methods 123 cases with melasma were divided randomly into the test group treated with BuJingXie Granule and LiQiYangXieHuoXie Granule, and the control group treated with BuJingHuoXie Granule. The survey was conducted on clinical effect after two periods of therapy.Results The total effective rate in the test group was 95.08%, and the control group was 93.22%.Comparison between the two groups showed no significant statistical difference（P＞0.05）. Conclusion The results suggested that the two therapy have a good effect in treating melasma. Their clinical effect were not difference.They are effective and safe medicine to treating melasma. Key words：melasma;therapy of periodical phase; pattern of deficiency of Yin of both liver and kidney; Therapy of Chinese Medicine 黄褐斑是发生于面部的常见色素沉着性皮肤病，以面部出现或浅或深的褐色斑片为主要症状，常见于眼眶附近、额颊、鼻口周围，可连成一片，祖国医学称之为“黧黑斑”、“肝斑”。该病多发生于孕妇或经血不调的妇女，部分患者可伴有其他慢性病，涂搽不适当的化妆品及日光照晒可加重黄褐斑[1]。从某种意义上讲，黄褐斑只是内在脏腑功能失调的一种外在表现。笔者根据女性的生理特点结合该病的主要病因病机，采用滋补肝肾与活血化瘀的周期性阶段疗法治疗了62例肝肾阴虚型黄褐斑患者，取得了较好的临床疗效，现将结果报道如下： 1 临床资料 1.1 诊断标准：参照中国中西医结合学会皮肤性病专业委员会色素病学组制定的《黄褐斑的临床诊断和疗效标准》(2003年修定稿)[2]：①面部淡褐色至深褐色、界限清楚的斑片，通常对称性分布，无炎症表现及鳞屑；②无明显自觉症状；③女性多发，主要发生在青春期后；④病情可有一定季节性，常夏重冬轻。 1.2 排除标准：①妊娠和哺乳期妇女、18岁以下或50岁以上者；②心脑血管、肝、肾、胃肠和造血系统严重疾病者、精神病患者；③停服避孕药不足半年者；④男性黄褐斑患者；⑤对治疗药物有过敏史者；⑥排除其他疾病(如：颧部