冠心病不同中医证型及FIB-HS-CRP相关性探究.doc

冠心病不同中医证型及FIB\HS-CRP相关性探究摘 要：目的：检测冠心病中医不同证型血浆纤维蛋白原（FIB）、血清超敏C反应蛋白（HS-CRP）水平,为冠心病的中医辨证分型提供客观依据,为冠心病的辨证论治提供参考。方法：将179例冠心病患者，中医辨证分为心血瘀阻、痰浊内阻、阴寒凝滞、心肾阴虚、气阴两虚、阳气虚衰型6组,选对照组30例，测定FIB、HS-CRP水平。结果：①各组中FIB测值高于正常的比例阳以气虚衰型最高，具体测值为阳气虚衰型＞阴寒凝滞型＞痰浊内阻型＞气阴两虚型＞心血瘀阻型＞心肾阴虚型＞对照组；冠心病中医证型中HS-CRP测值为心血瘀阻型＞阳气虚衰型＞痰浊内阻型＞阴寒凝滞型＞对照组＞气阴两虚型＞心肾阴虚型。②7组的FIB及HS-CRP水平的两两比较的21对中，均为6对有统计学差异，15对无统计学差异；③急性冠脉综合征（ACS）的阳性率在冠心病的6证型组中有统计学差异。结论 FIB、HS-CRP对冠心病中医辨证分型有一定参考价值，尤其是FIB在阳气虚衰型，HS-CRP在心血瘀阻型中的作用更大。 关键词：冠心病；纤维蛋白原；超敏C反应蛋白；中医辩证分型 中图分类号：R541.4 文献标识码：A 文章编号：1673-7717（2011）04-0677-03 Clinical Study of Relationships Between FIB HS-CRP Respectively in CHD with Various TCM Syndromes XING Zhi-hua【sup】1【/sup】，XU Cai-yun【sup】1【/sup】，LIU Wei-ping【sup】1【/sup】，YANG Tian-lun【sup】2【/sup】，XIAO Yan-ping【sup】1【/sup】，CUI Han-jing【sup】1【/sup】 （1.Institute of Combined Traditional Chinese and Westem Medicine，Xiangya Hospital， Central South University， Department of Integrated Chinese and Western Medicine, and Key Lab of Gan State Administration of Traditional Chinese Medicine of China, Xiangya Hospital, Central South University, Changsha 410008,Hunan,China； 2.Department of Cardiology, Xiangya Hospital, Central South University, Changsha 410008, Hunan,China） Abstract:Objective: The study is to provide an objective proof for syndrome differentiation of traditional Chinese medecine （TCM） and guide clinical treatment and syndromes in coronary heart disease （CHD）. Methods: The patients with CHD were divided into 6 groups, such as heart blood stasis, retention of phlegm in heart vessel, stagnation of qi due to cold, heart - kidney yin deficiency, dual deficiency of qi and yin, dual deficiancy yang and qi.30members of the control group were randomly selected from the medical center . The levels of fibrinogen（fib）and high-sensititive reactive protein（HS-CRP） has been detectded. Results: The levels of fibrinogen（fib） of dual deficiancy yang and qi group were statistically higher than those of control group. hear