多西环素及维A酸霜及两者联合使用治疗酒渣鼻疗效比较探究.docVIP

多西环素及维A酸霜及两者联合使用治疗酒渣鼻疗效比较探究[摘要]目的：探讨比较口服多西环素、外用维A酸霜以及两者联合使用治疗酒渣鼻的疗效和安全性。方法:将就诊于我院的酒渣鼻患者共60名，随机分为三组：口服多西环素治疗组、外用维A酸霜治疗组及两者联合治疗组，观察比较三组治疗前后炎症损害数目、红斑评分、毛细血管扩张严重程度的变化情况。结果：治疗12周后，联合治疗组的疗效优于另外两组（P＜0.05），而多西环素组与维A酸组的疗效相当（P＞0.05），三组中仅发生5例短暂轻微的副作用。结论：多西环素和维A酸外用制剂治疗酒渣鼻均能达到很好的疗效，发生的副作用轻微且短暂，两者联合应用的疗效更为显著，但均无改善毛细血管扩张症状的作用。 [关键词]酒渣鼻；多西环素；维A酸；药物治疗 [中图分类号]R758.73+4 [文献标识码]A [文章编号]1008-6455（2011）03-0450-03 Comparing the therapeutic effect of oral doxycycline, topical tretinoin and their combination therapy in treatment of rosacea LAI Jin-dong，YANG Juan (Department of Dermatology,The Fist People’s Hospital,Suining 62900,Sichuan,China) Abstract：Objective To evaluate the therapeutic effect and security of oral doxycycline, topical tretinoin and their combination therapy in treatment of rosacea.Methods60 patients who suffered rosacea were randomly divided into three groups:the oral Doxycycline treatment group,topical tretinoin cream treatment groupand their combination treatment group. We compared the changes in the number of inflammatory lesions,erythema scores and the severity of telangiectasia before and after the treatment.ResultsAfter 12 weeks of treatment,we found thatthe therapeutic effect of combination group was better than the other two groups(P＜0.05), and a considerable therapeutic effect was achieved in both doxycycline group and tretinoin group(P＞0.05).there were only 5 cases involved in transient and minor adverse effect.ConclusionsExcellent therapeutic effect with mild and transient adverse could be achieved by oral doxycycline and topical tretinoin, and their combination therapy was better, but they had no improvement in telangiectasia. Key words：rosacea；Doxycycline；tretinoin；drug therapy 酒渣鼻是一种常见的、慢性充血性皮肤病，以反复发作的面部红斑，并发丘疹、脓疱、毛细血管扩张、水肿和组织纤维化为特征。美国国家酒渣鼻协会专委会（NRSEC）[1]将酒渣鼻分为四种主要的亚型：红斑毛细血管扩张型，丘疹脓疱型，肿块型，眼型。患者通常会有一种亚型以上的特征性表现，病情可由一种亚型进展至新亚型，也可不进展。为了观察口服多西环素联合外用维A酸霜治疗酒渣鼻的疗效和安全性，2006年6月～2010年12月，笔者选用口服多西环素、外用维A酸霜（0.025%）以及两者联合使用来治疗酒渣鼻患者，并观察联合应用的疗效和安全性，