妇科门诊高危型子宫颈人乳头状瘤病毒感染情况研究.docVIP

妇科门诊高危型子宫颈人乳头状瘤病毒感染情况研究[摘要] 目的 调查妇科门诊患者高危型人乳头瘤病毒（HPV）感染情况。方法 2010 年1 月至2010 年12月，对3214 名妇女采用第二代杂交捕获试验（HC- Ⅱ）检测高危型HPVDNA检查。审核数据后，采用SPSS10．0软件进行统计学分析。结果 受检者平均年龄（34 ± 8 ）岁，其中高危型HPVDNA检测阳性者 738例，占22.97％；阴性者2476例，占77.03％。高危型HPVDNA阳性患者的年龄为19-68岁，其中20-29岁和30-39岁者者感染率最高，分别为26.40％和20.76 ％(P＜0.01)。单一高危HPV DNA感染率为54.32％，多重高危HPV DNA亚型感染32.13%(P＜0.01)。 多重亚型感染中，一般以2-3种亚型感染为多见，占28.56％(P＜0.01)，感染率最高的亚型为HPV 16、58、33、18，31.26％(231例)、18.26％(135例)、10.28％(76例)和10.19％(75例)。结论 妇科门诊患者高危型HPV DNA 感染率高，应对感染者定期随访以了解感染的动态变化。 [关键词]人乳头状瘤病毒； 感染; 调查 [中图分类号] R73-31[文献标识码] A[文章编号] 1005-0515（2011）-02-027-01 Study of high risk human papillomavirus infection conditions among the women in obstetrics clinic Zhang zhongping (Haiyang People’s Family planning committee service center，Shandong 265100) [Abstract] Objective To investigate high-risk human papillomavirus(HR-HPV) infection conditions among the women in obstetrics clinic．Methods During January 2010 to December 2010，a total of 3214 women were screened by combining high-risk HPV DNA test （hybrid capture Ⅱ，HC- Ⅱ）．After checked up，the data were analyzed in spss 10.0. ResultsThe average age of the patients was 34± 8． Final diagnosiswas HR-HPV infection in 738 cases，Their age was between 19 to 68．The age distribution of HR．HPV infection was hishest in 20 to29 and30 to39 age group，The rate were26.40％and20.76 ％(P＜0.01).The rate of single HR-HPV infection was 54.32％ and multiple was 32.13%(P＜0.01).There were 2 or 3 subtypes among multiple infection，the rate was 28.56％(P＜0.01).HR-HPV 16、58、33、18 were the highest infected subtypes，the rate were 31.26％、18.26％、10.28％ and 10.19％. Conclusions The HR-HPV infection rate was high among the women in obstetrics clinic．The high risk population should be checked regularly to understand the development of HR-HPV infection. [Keywords]Human papillomavirus； infection； rural area 人乳头状瘤病毒（HPV）在女性人群中感染率较高，宫颈癌的病因学研究已得出结论，高危型人乳头状瘤病毒感染是宫颈癌及癌前病变发病的主要危险因素。虽然国内有关HPV DNA在女性人群中感染率的报道已屡见不鲜。为了解妇科门诊女性高危型宫颈HPV感染情况，