抗增殖蛋白研究进展.PDF

第22卷 第5期 生命科学 Vol. 22, No. 5 2010年5月 Chinese Bulletin of Life Sciences May, 2010 文章编号 ：1004-0374(2010)05-0405-06 抗增殖蛋白研究进展 1 1，2 1 1* 陈　操 ，刘　欣 ， 孙　晶 ，李庆伟 (1 辽宁师范大学海洋生物功能基因及蛋白质组学研究所，大连116029；2 辽宁师范大学城市与环境学院，大连116029) 摘　要：抗增殖蛋白作为一种高度保守的蛋白广泛分布于细菌、原虫、酵母等多种生物细胞中，主要 定位于细胞膜、线粒体内膜、细胞核中，参与细胞增殖、分化、衰老、凋亡等多种生物学进程。 由于抗增殖蛋白结构进化上的保守性和功能的多样性，正逐渐引起广泛的关注。该文正是基于抗增殖蛋 白重要的生物学意义，通过对其基因结构和功能的分析，系统地阐述了它在生物体中发挥的重要作用， 并对其应用前景作以展望。 关键词：抗增殖蛋白；结构；定位；生物学功能 中图分类号：Q 5 1 　　文献标识码：A The research progress of prohibitin 1 1,2 1 1 CHEN Cao , LIU Xin , SUN Jing , LI Qing-wei * (1 Institute of Marine Genomics Proteomics, Liaoning Normal University, Dalian 116029, China; 2 College of Urban and Environmental Sciences, Liaoning Normal University, Dalian 116029, China) Abstract: Prohibitin ( PHB) is a highly conserved protein and ubiquitously distributed in different cellular compartments of various organisms.Various roles have been proposed for prohibitin involving multibiological processes such as cell cycle regulation, cell proliferation, cell aging and cell apoptosis, etc. Due to its highly conserved structure in evolution and diverse functions, PHB has gradually caused widespread concern. This article systematically discussed the important functions of PHB in organisms based on the latest researches worldwide about the its structure and functions, and furthermore, its applied prospect in the future was outlooked. Key words: prohibitin; structure; location; biological function 抗增殖蛋白作为一种高度保守的蛋白，广泛分 为一种核基因编码的蛋白质被认为是核内转录调控因 布于细菌、植物、酵母、原虫