超高分子量聚乙烯纤维对金黄地鼠口腔黏膜的刺激实验.pdfVIP

；震基础实验 J 中国组织工程研究与临床康复 ， 拳 ，崩r 2008一Ol一叭出版 ournal ofClinical Rehabilitative Tissue Engineering Research January 1．2008 VoL 12,No t 超高分子量聚乙烯纤维对金黄地鼠口腔黏膜的刺激实验★ 邱晓霞，王 桃，莫三心 Irritation of ultrahigh molecular weight polyethylene fiber to oral mucous membrane of golden hamsters Qiu Xiao-xia，Wang Tao，Mo San-xin Abstract Dcpa．,tl~nt of Oral AIM：To evaluate Ribbond ultrahigh molecular weight polyethylene fiber(UMWPF)on hamster’s pouch by oral membrane irritation． Prosthcfics,College ot METHODS：Experiments were performed at the Animal Experimental Center of Henan Province from July to December 2004．Ten Stomatology, Zheng- zhou Umvessity, healthy male golden hamsters aged 60—70 days were selected．The samples of UMWPF，positive and negative control group =lO， 刁Ⅻ 出∞ 450052， diameter 4 mm．thickness l mm)were fixed on the oral membrane of hamster’s pouch with medical thread．The thread should pass HenmaProvince,China through membrane and fixed on the animals’skin．Th e experimental sam ples were on the one side of pouch membrane rUMWPF toward membrane)；the positive and negative samples were on the cephalic and tail of the other side respectively．After two weeks’ Qiu Xiao-xia ★ Master, Associate systemic and local observation，the local oral membrane specimens were viewed under microscope． professor, Associate 1 SIlLTS：Totally l0 hamsters were included in the final analysis．①2 weeks after the surgery，the animals pouch membrane chief physician, contacting with the experiment and negative samples showed no hyperemia，hydrops，erosion or ulcer，and where positive samples De0aiullcnt of Oral contacted showed rough；7 of them showed light hyperemia and hydrops．@The epithelia layer of the animal membrane contacting Proslh~es,College ot