体外循环状态下血液肿瘤坏死因子α、白细胞介素8、白细胞介素10水平的变化.pdfVIP

I、1 临床医学 ~ 中国组织工程研究与临床康复 J2誊第 筋r 2008一Ol一29出版 umal ofClinical Rehabilitative 17ssue Engineering Research January 29,2008 Vo1．12，No．5 体外循环状态下血液肿瘤坏死因子Q、 白细胞介素8、白细胞介素10 水平的变化★★ 高增栋’，仲崇俊。，陆晨希。，刘 麟。 Changes in serum tumor necrosis factor alpha， interleukin-8 and interleukin一10 levels under cardiopulmonary bypass Gao Zeng—dong’Zhong Chong-jun。，Lu Chen—xi。，Liu Lin。 ， Abstract Department of AIM：Cardiopulmonary bypass(CPB)induces an ncrease in the levels of inflammatory mediators．resulting in lung injury during Intensive Care Unit， ‘De partment of heart transplantation and open heart surgery．Open lung concept(OLC)improves lung injury after CPB．This study aimed to Cardiothuracic investigate the effects of OLC on pulmonary function and the levels of tumor necrosis factor．alpha(TNF．tt)，interleukin．8(IL．8)and Surgery， De partment 【L．10 in patients after CPB． of Anesthesiology， METH0DS： Sixty patients undergoing open heart surgery under general anesthesia，low temperature and CPB were enrolled at Second Affiliated Department of Cardiothoracic Surgery，Second Affiliated Hospital，Nantong University from October 2oo5 to October 2oo7．AIl Hospital， Nantong University, Nantong patients singed informed consents．( A total of 60 patients were divided at random into conventional mechanical ventilation(CMV) 226ool， Jiangsu group，early open lung(E0L)group and late open lung(LOL)group with 20 in each group．Patients in the E0L group received OLC Province，China after tracheaIintubation，whereas patients in the LOL group received OLC 30 minutes after arriving the intensive care unit(ICU)．③ Levels of TNF．tt IL．8 and IL．10 were measured with enzyme．1abeled immunosorbent assay(ELISA)before surgery，after CPB and Gao Zeng·dong★ ．